Quantum Biochemistry Screening and In Vitro Evaluation of Leishmania Metalloproteinase Inhibitors

Leishmanolysin, also known as major promastigote protease (PSP) or gp63, is the most abundant surface glycoprotein of Leishmania spp., and has been extensively studied and recognized as the main parasite virulence factor. Characterized as a metalloprotease, gp63 can be powerfully inactivated in the...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 23; no. 15; p. 8553
Main Authors:	Moreno, Cláudia Jassica Gonçalves, Farias, Henriqueta Monalisa, Medeiros, Rafael, Brito, Talita, Oliveira, Johny, de Sousa, Francimar Lopes, Medeiros, Mayara Jane Campos de, Amorim, Bruno, Santos-Gomes, Gabriela, Pontes, Daniel, Rocha, Hugo Alexandre Oliveira, Frazao, Nilton Fereira, Silva, Marcelo Sousa
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-08-2022 MDPI
Subjects:	Amino acids Biochemistry Carbon Chelating agents Chemical bonds Computer applications Cytotoxicity Doxycycline Energy Etiology Extracellular matrix Glycoproteins Hydrogen bonds Infections Inhibitors Leishmania Leishmania spp Leishmaniasis Leishmanolysin Ligands metalloprotease inhibitors Metalloproteinase MFCC (Molecular Fractionation with Conjugate Caps) Molecular docking Necrosis Parasites Parasitic diseases Proteins Spectroscopy Terpineol Three dimensional analysis Virulence factors
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