Advancement in biosensors for inflammatory biomarkers of SARS-CoV-2 during 2019–2020

• Published in: Biosensors & bioelectronics Vol. 171; p. 112703
• Main Authors: Garg, Mayank, Sharma, Amit L., Singh, Suman
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01-01-2021
• Subjects: Animals; Betacoronavirus - isolation & purification; Biomarkers - analysis; Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Biosensors; C-Reactive Protein - analysis; C-reactive proteins; Clinical Laboratory Techniques; Coronavirus Infections - diagnosis; COVID-19; COVID-19 Testing; Equipment Design; Ferritin; Ferritins - analysis; Humans; Inflammation - diagnosis; Inflammatory markers; Interleukin-6; Interleukin-6 - analysis; Pandemics; Pneumonia, Viral - diagnosis; Procalcitonin; Procalcitonin - analysis; SARS-CoV-2; SARS-CoV-2; C-reactive proteins; Procalcitonin; Ferritin; Inflammatory markers; Biosensors; Interleukin-6
• ISSN: 0956-5663; 1873-4235
• DOI: 10.1016/j.bios.2020.112703

COVID-19 pandemic has affected everyone throughout the world and has resulted in the loss of lives of many souls. Due to the restless efforts of the researchers working hard day and night, some success has been gained for the detection of virus. As on date, the traditional polymerized chain reactions (PCR), lateral flow devices (LFID) and enzyme linked immunosorbent assays (ELISA) are being adapted for the detection of this deadly virus. However, a more exciting avenue is the detection of certain biomarkers associated with this viral infection which can be done by simply re-purposing our existing infrastructure. SARS-CoV-2 viral infection triggers various inflammatory, biochemical and hematological biomarkers. Because of the infection route that the virus follows, it causes significant inflammatory response. As a result, various inflammatory markers have been reported to be closely associated with this infection such as C-reactive proteins, interleukin-6, procalcitonin and ferritin. Sensing of these biomarkers can simultaneously help in understanding the illness level of the affected patient. Also, by monitoring these biomarkers, we can predict the viral infections in those patients who have low SARS-CoV-2 RNA and hence are missed by traditional tests. This can give more targets to the researchers and scientists, working in the area of drug development and provide better prognosis. In this review, we propose to highlight the conventional as well as the non-conventional methods for the detection of these inflammatory biomarkers which can act as a single platform of knowledge for the researchers and scientists working for the treatment of COVID-19.
•Inflammatory, biochemical and hematological biomarkers triggered by SARS-CoV-2.•Inflammatory biomarkers include CRP, IL-6, PCT and ferritin.•Monitoring these help in understanding the illness level of the affected patient.•Review highlight the conventional as well as the non-conventional detection methods.•Biosensors are potential candidates for monitoring infections.