Factors Predicting and Having an Impact on the Need for a Permanent Pacemaker After CoreValve Prosthesis Implantation Using the New Accutrak Delivery Catheter System

• Published in: JACC. Cardiovascular interventions Vol. 5; no. 5; pp. 533 - 539
• Main Authors: Muñoz-García, Antonio J., MD, PhD, Hernández-García, José M., MD, PhD, Jiménez-Navarro, Manuel F., MD, PhD, Alonso-Briales, Juan H., MD, Domínguez-Franco, Antonio J., MD, Fernández-Pastor, Julia, MD, Peña Hernández, Jose, MD, Barrera Cordero, Alberto, MD, Alzueta Rodríguez, Javier, MD, PhD, de Teresa-Galván, Eduardo, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-05-2012
• Subjects: Aged; Aged, 80 and over; aortic stenosis; Aortic Valve Stenosis - diagnosis; Aortic Valve Stenosis - therapy; Bundle-Branch Block - diagnosis; Bundle-Branch Block - etiology; Bundle-Branch Block - therapy; Cardiac Catheterization - adverse effects; Cardiac Catheterization - instrumentation; Cardiac Pacing, Artificial; Cardiovascular; Catheters; Chi-Square Distribution; Electrocardiography; Equipment Design; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation - adverse effects; Heart Valve Prosthesis Implantation - instrumentation; Humans; Male; Multivariate Analysis; Pacemaker, Artificial; pacemakers; Proportional Hazards Models; prosthesis; Prosthesis Design; Risk Assessment; Risk Factors; Severity of Illness Index; Spain; Time Factors; transcatheter aortic valve implantation; Treatment Outcome; Spain; pacemakers; transcatheter aortic valve implantation; right bundle branch block; TAVI; ECG; left ventricular outflow tract; left bundle branch block; LVOT; atrioventricular; electrocardiogram; aortic stenosis; AV; LBBB; RBBB; prosthesis; traditional system; TS
• ISSN: 1936-8798; 1876-7605
• DOI: 10.1016/j.jcin.2012.03.011

Objectives The purpose of this study was to evaluate the need for a permanent pacemaker after transcatheter aortic valve implantation with the CoreValve prosthesis (Medtronic, Inc., Minneapolis, Minnesota) using the new Accutrak delivery system (Medtronic, Inc.). Background The need for a permanent pacemaker is a recognized complication after transcatheter aortic valve implantation with the CoreValve prosthesis. Methods Between April 23, 2008 and May 31, 2011, 195 consecutive patients with symptomatic aortic valve stenosis underwent transcatheter aortic valve implantation using the self-expanding CoreValve prosthesis. In 124 patients, the traditional delivery system was used, and in 71 patients, the Accutrak delivery system was used. Results There were no significant differences in baseline electrocardiographic characteristics between the traditional system and the Accutrak patients: PR interval: 153 ± 46 mm versus 165 ± 30 mm, p = 0.12; left bundle branch block: 22 (20.2%) versus 8 (12.7%), p = 0.21; right bundle branch block: 21 (19.3%) versus 8 (12.7%), p = 0.26. The depth of the prosthesis in the left ventricular outflow tract was greater with the traditional system than with the Accutrak system (9.6 ± 3.2 mm vs. 6.4 ± 3 mm, p < 0.001) and the need for a permanent pacemaker was higher with traditional system than with Accutrak (35.1% vs. 14.3%, p = 0.003). The predictors of the need for a pacemaker were the depth of the prosthesis in the left ventricular outflow tract (hazard ratio [HR]: 1.2, 95% confidence interval [CI]: 1.08 to 1.34, p < 0.001), pre-existing right bundle branch block (HR: 3.5, 95% CI: 1.68 to 7.29, p = 0.001), and use of the traditional system (HR: 27, 95% CI: 2.81 to 257, p = 0.004). Conclusions The new Accutrak delivery system was associated with less deep prosthesis implantation in the left ventricular outflow tract, which could be related to the lower rate of permanent pacemaker requirement.