Isolation of Corynebacterium ureicelerivorans from normally sterile sites in humans

• Published in: European journal of clinical microbiology & infectious diseases Vol. 28; no. 6; pp. 677 - 681
• Main Authors: Fernández-Natal, M. I, Sáez-Nieto, J. A, Valdezate, S, Rodríguez-Pollán, R. H, Lapeña, S, Cachón, F, Soriano, F
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01-06-2009; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Animals; Bacteremia - microbiology; Bacterial Proteins - genetics; Bacterial Typing Techniques; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cluster Analysis; Concise Article; Corynebacterium; Corynebacterium - classification; Corynebacterium - genetics; Corynebacterium - isolation & purification; Corynebacterium Infections - microbiology; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; DNA, Ribosomal - chemistry; DNA, Ribosomal - genetics; DNA-Directed RNA Polymerases - genetics; Female; Humans; Infectious diseases; Internal Medicine; Male; Medical Microbiology; Medical sciences; Microbial Sensitivity Tests; Middle Aged; Molecular Sequence Data; Peritonitis - microbiology; Phylogeny; RNA, Ribosomal, 16S - genetics; Sequence Analysis, DNA; Urea; Linezolid; Ascitic Fluid; Clarithromycin; Diverticulitis; Blood Agar; Human; Infection; Corynebacterium; Microbiology; Bacteria; Isolation; Actinomycetes; Corynebacteriaceae
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-008-0677-1

Fifteen Corynebacterium ureicelerivorans isolates were recovered in pure culture from six patients during a five-year period. Five patients had bacteremia and the other was an infection of ascitic fluid. The API Coryne[trade mark sign] numerical profile obtained corresponds to the profile for C. bovis, while Biolog[trade mark sign] GP2 identified four out of the six isolates as C. jeikeium. The organisms were molecular identified by 16S rDNA and rpoB. The present report also includes information on new phenotypic tests and, for the first time, antimicrobial susceptibility data of C. ureicelerivorans and their rpoB sequences. All macrolide-resistant isolates presented a constitutive MLS phenotype. This organism must be differentiated from other slow-growing, lipophilic, and urea-splitting corynebacteria.