Validation of T-Track® CMV to assess the functionality of cytomegalovirus-reactive cell-mediated immunity in hemodialysis patients

Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Primary aim of this study was to assess the suitability of the immune monitoring tool T-Track®...

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Bibliographic Details
Published in:	BMC immunology Vol. 18; no. 1; p. 15
Main Authors:	Banas, Bernhard, Böger, Carsten A, Lückhoff, Gerhard, Krüger, Bernd, Barabas, Sascha, Batzilla, Julia, Schemmerer, Mathias, Köstler, Josef, Bendfeldt, Hanna, Rascle, Anne, Wagner, Ralf, Deml, Ludwig, Leicht, Joachim, Krämer, Bernhard K
Format:	Journal Article
Language:	English
Published:	England BioMed Central 07-03-2017
Subjects:	Adult Aged Aged, 80 and over Antibodies, Viral - blood Antigens Cell division Cell-mediated immunity Cells, Cultured Chicken pox Cohort Studies Cross-reactivity Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - immunology Female Flow cytometry Hemodialysis Herpes viruses Humans Immediate-Early Proteins - immunology Immune response Immune response (humoral) Immune system Immunity, Cellular Immunoassay Immunocompromised Host Infections Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - immunology Kidney Failure, Chronic - therapy Kidney Transplantation Lymphocytes Lymphocytes T Major histocompatibility complex Male Middle Aged Monitoring, Immunologic - methods Observer Variation Patients Peptides Phosphoproteins - immunology Pp65 protein Proteins Renal Dialysis Sensitivity and Specificity Serology Software T cell receptors Transplants & implants Viral infections Viral Matrix Proteins - immunology Waiting Lists Germany Cytomegalovirus IE-1 Cell-mediated immunity Hemodialysis IFN-γ ELISpot QuantiFERON®-CMV pp65 CMV T-Track® CMV iTAg™ MHC Tetramers
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