Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway

Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2•-) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an H2O2-mediated redox signaling circuit...

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Published in:	Biochemical and biophysical research communications Vol. 534; pp. 720 - 726
Main Authors:	Chandrasekharan, Bindu, Montllor-Albalate, Claudia, Colin, Alyson E., Andersen, Joshua L., Jang, Young C., Reddi, Amit R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-01-2021
Subjects:	Cancer Casein Kinase I - metabolism Cell Proliferation - physiology Cu/Zn superoxide dismutase Gene Expression Regulation HEK293 Cells Humans Hydrogen peroxide Reactive oxygen species Redox signaling RNA Interference Superoxide Superoxide Dismutase-1 - genetics Superoxide Dismutase-1 - metabolism Wnt signaling Wnt Signaling Pathway - physiology Reactive oxygen species Wnt signaling Hydrogen peroxide Cu/Zn superoxide dismutase Superoxide Redox signaling Cancer
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Abstract	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2•-) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an H2O2-mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. In response to glucose and O2, Sod1-derived H2O2 stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration. The Yck1/2 homolog in humans, casein kinase 1-γ (CK1γ), is an integral component of the Wingless and Int-1 (Wnt) signaling pathway, which is essential for regulating cell fate and proliferation in early development and adult tissue and is dysregulated in many cancers. Herein, we establish the conservation of the SOD1/YCK1 redox signaling axis in humans by finding that SOD1 regulates CK1γ expression in human embryonic kidney 293 (HEK293) cells and is required for canonical Wnt signaling and Wnt-dependent cell proliferation. •Cu/Zn Superoxide Dismutase (Sod1) is a well conserved and abundant antioxidant enzyme.•Sod1 plays important roles in redox signaling due to its production of H2O2.•Sod1 regulates the canonical Wnt signaling pathway.
AbstractList	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O ) into oxygen (O ) and hydrogen peroxide (H O ), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an H O -mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. In response to glucose and O , Sod1-derived H O stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration. The Yck1/2 homolog in humans, casein kinase 1-γ (CK1γ), is an integral component of the Wingless and Int-1 (Wnt) signaling pathway, which is essential for regulating cell fate and proliferation in early development and adult tissue and is dysregulated in many cancers. Herein, we establish the conservation of the SOD1/YCK1 redox signaling axis in humans by finding that SOD1 regulates CK1γ expression in human embryonic kidney 293 (HEK293) cells and is required for canonical Wnt signaling and Wnt-dependent cell proliferation. Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2•-) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an H2O2-mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. In response to glucose and O2, Sod1-derived H2O2 stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration. The Yck1/2 homolog in humans, casein kinase 1-γ (CK1γ), is an integral component of the Wingless and Int-1 (Wnt) signaling pathway, which is essential for regulating cell fate and proliferation in early development and adult tissue and is dysregulated in many cancers. Herein, we establish the conservation of the SOD1/YCK1 redox signaling axis in humans by finding that SOD1 regulates CK1γ expression in human embryonic kidney 293 (HEK293) cells and is required for canonical Wnt signaling and Wnt-dependent cell proliferation. Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2•-) into oxygen (O2) and hydrogen peroxide (H2O2), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an H2O2-mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. In response to glucose and O2, Sod1-derived H2O2 stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration. The Yck1/2 homolog in humans, casein kinase 1-γ (CK1γ), is an integral component of the Wingless and Int-1 (Wnt) signaling pathway, which is essential for regulating cell fate and proliferation in early development and adult tissue and is dysregulated in many cancers. Herein, we establish the conservation of the SOD1/YCK1 redox signaling axis in humans by finding that SOD1 regulates CK1γ expression in human embryonic kidney 293 (HEK293) cells and is required for canonical Wnt signaling and Wnt-dependent cell proliferation. •Cu/Zn Superoxide Dismutase (Sod1) is a well conserved and abundant antioxidant enzyme.•Sod1 plays important roles in redox signaling due to its production of H2O2.•Sod1 regulates the canonical Wnt signaling pathway. Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O 2 •− ) into oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ), a key signaling molecule. In Saccharomyces cerevisiae , we previously discovered that Sod1 participates in an H 2 O 2 -mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. In response to glucose and O 2 , Sod1-derived H 2 O 2 stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration. The Yck1/2 homolog in humans, casein kinase 1-γ (CK1γ), is an integral component of the Wingless and Int-1 (Wnt) signaling pathway, which is essential for regulating cell fate and proliferation in early development and adult tissue and is dysregulated in many cancers. Herein, we establish the conservation of the SOD1/YCK1 redox signaling axis in humans by finding that SOD1 regulates CK1γ expression in human embryonic kidney 293 (HEK293) cells and is required for canonical Wnt signaling and Wnt-dependent cell proliferation.
Author	Andersen, Joshua L. Chandrasekharan, Bindu Colin, Alyson E. Reddi, Amit R. Montllor-Albalate, Claudia Jang, Young C.
AuthorAffiliation	a School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 c Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332 d Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602 b School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332
AuthorAffiliation_xml	– name: b School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332 – name: c Parker Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332 – name: d Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602 – name: a School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332
Author_xml	– sequence: 1 givenname: Bindu surname: Chandrasekharan fullname: Chandrasekharan, Bindu organization: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA – sequence: 2 givenname: Claudia orcidid: 0000-0003-0001-0236 surname: Montllor-Albalate fullname: Montllor-Albalate, Claudia organization: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA – sequence: 3 givenname: Alyson E. surname: Colin fullname: Colin, Alyson E. organization: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA – sequence: 4 givenname: Joshua L. surname: Andersen fullname: Andersen, Joshua L. organization: Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA – sequence: 5 givenname: Young C. surname: Jang fullname: Jang, Young C. organization: School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA – sequence: 6 givenname: Amit R. surname: Reddi fullname: Reddi, Amit R. email: amit.reddi@chemistry.gatech.edu organization: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA
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Keywords	Reactive oxygen species Wnt signaling Hydrogen peroxide Cu/Zn superoxide dismutase Superoxide Redox signaling Cancer
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author Contributions. BC, CMA, and AEC designed and performed experiments. JLA and YCJ designed experiments. BC, CMA, and ARR wrote the manuscript with input from all authors.
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Snippet	Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O2•-) into oxygen (O2) and hydrogen peroxide (H2O2), a key... Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O ) into oxygen (O ) and hydrogen peroxide (H O ), a key... Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O 2 •− ) into oxygen (O 2 ) and hydrogen peroxide (H 2 O 2...
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SubjectTerms	Cancer Casein Kinase I - metabolism Cell Proliferation - physiology Cu/Zn superoxide dismutase Gene Expression Regulation HEK293 Cells Humans Hydrogen peroxide Reactive oxygen species Redox signaling RNA Interference Superoxide Superoxide Dismutase-1 - genetics Superoxide Dismutase-1 - metabolism Wnt signaling Wnt Signaling Pathway - physiology
Title	Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway
URI	https://dx.doi.org/10.1016/j.bbrc.2020.11.011 https://www.ncbi.nlm.nih.gov/pubmed/33218686 https://search.proquest.com/docview/2463106058 https://pubmed.ncbi.nlm.nih.gov/PMC7785591
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