Studies on the teratogenicity of anabasine in a rat model

A number of plant toxins have been shown to be teratogenic to livestock. The teratogenic action of some of these alkaloids is mediated by nicotinic acetylcholine receptors (nAChR). However, for many of these alkaloids it is difficult to obtain sufficient quantities of individual alkaloids to perform...

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Bibliographic Details
Published in:	Toxicon (Oxford) Vol. 87; pp. 32 - 37
Main Authors:	Welch, K.D., Lee, S.T., Panter, K.E., Gardner, D.R., Knoppel, E.L., Green, B.T., Hammond, C.K., Hammond, Z.J., Pfister, J.A.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2014
Subjects:	abnormal development Abnormalities, Drug-Induced - pathology agonists Alkaloids Anabasine Anabasine - toxicity animal models Animals asphyxia body weight Body Weight - drug effects Bones carbon dioxide cattle cesarean section cholinergic receptors cleft palate dams (mothers) Dose-Response Relationship, Drug Eating - drug effects Feeding Female goats Livestock Male Nicotiana glauca Nicotinic acetylcholine receptor oral administration phytotoxins Plant toxins Pregnancy pups Rat Rats Reproduction - drug effects Rodents scoliosis sheep Teratogen Teratogenicity Teratogens - toxicity Toxins Toxins, Biological - toxicity ultrasonography Teratogen Rat Anabasine Plant toxins Nicotinic acetylcholine receptor
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