Flavopiridol, Fludarabine, and Rituximab in Mantle Cell Lymphoma and Indolent B-Cell Lymphoproliferative Disorders

Flavopiridol downmodulates antiapoptotic proteins associated with resistance to fludarabine and rituximab and is effective against p53-mutated chronic lymphocytic leukemia (CLL). We conducted a phase I study of flavopiridol, fludarabine, and rituximab (FFR) in patients with mantle-cell lymphoma (MCL...

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Bibliographic Details
Published in:	Journal of clinical oncology Vol. 28; no. 3; pp. 418 - 423
Main Authors:	LIN, Thomas S, BLUM, Kristie A, SCHAAF, Larry J, GREVER, Michael R, BYRD, John C, BETH FISCHER, Diane, MITCHELL, Sarah M, RUPPERT, Amy S, PORCU, Pierluigi, KRAUT, Eric H, BAIOCCHI, Robert A, MORAN, Mollie E, JOHNSON, Amy J
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Society of Clinical Oncology 20-01-2010
Subjects:	Adult Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Murine-Derived Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-Lymphocytes Biological and medical sciences Female Flavonoids - administration & dosage Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - drug therapy Lymphoma, Mantle-Cell - drug therapy Lymphoproliferative Disorders - drug therapy Male Medical sciences Middle Aged Original Reports Piperidines - administration & dosage Rituximab Tumors Vidarabine - administration & dosage Vidarabine - analogs & derivatives Antineoplastic agent Purine nucleotide Purine derivatives Rituximab B cell neoplasm Malignant hemopathy B-Lymphocyte Nucleotide analog Monoclonal antibody Non Hodgkin lymphoma Flavonoid Cyclin dependent kinase inhibitor Polyphenol Cancerology Flavopiridol Fludarabine Treatment Antimetabolic Immunotherapy Lymphoproliferative syndrome Mantle cell lymphoma Phenols Fluorine Organic compounds Cancer
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