Effects of Lanthanum on Human Lymphocytes Viability and DNA Strand Break
Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is an increased risk of contamination for humans. We examined the effects of lanthanum in Jurkat cells and human peripheral lymphocytes (HPL),...
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| Published in: | Bulletin of environmental contamination and toxicology Vol. 82; no. 4; pp. 423 - 427 |
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| Format: | Journal Article |
| Language: | English |
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01-04-2009
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| Abstract | Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is an increased risk of contamination for humans. We examined the effects of lanthanum in Jurkat cells and human peripheral lymphocytes (HPL), and we found that it was cytotoxic and genotoxic on both cell lines. Additionally, HPL were more sensitive to La treatment than Jurkat cells and necrosis was the pathway by which La induced cytotoxicity. Vitamin E was able to diminish the DNA strand breaks induced suggesting that oxidative stress may be involved in the genotoxic process. |
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| AbstractList | The effect of lanthanum (La) on human lymphocytes viability and DNA strand break was assessed. Cellular viability, necrosis, and apoptosis were analyzed in three time intervals -0, 24, and 48 h with La(NO sub(3)) sub(3). The cells were analyzed through microscopic observation to determine the survival ratio (N/N sub(o)). After testing La(NO sub(3)) sub(3) in a range of dose from 0.25 to 5 mM, and 24 h after incubation, both Jurkat and HPL cells revealed an increase of necrotic cells indices. The results showed that necrosis was the pathway by which La(NO sub(3)) sub(3) induced cytotoxicity. La(NO sub(3)) sub(3) caused a significant increase in arbitrary units compared to unexposed control. It was concluded that genotoxic effect was observed for La concentrations equal or higher than 0.25 mM and diminished in the presence of Trolox. Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is an increased risk of contamination for humans. We examined the effects of lanthanum in Jurkat cells and human peripheral lymphocytes (HPL), and we found that it was cytotoxic and genotoxic on both cell lines. Additionally, HPL were more sensitive to La treatment than Jurkat cells and necrosis was the pathway by which La induced cytotoxicity. Vitamin E was able to diminish the DNA strand breaks induced suggesting that oxidative stress may be involved in the genotoxic process. Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is an increased risk of contamination for humans. We examined the effects of lanthanum in Jurkat cells and human peripheral lymphocytes (HPL), and we found that it was cytotoxic and genotoxic on both cell lines. Additionally, HPL were more sensitive to La treatment than Jurkat cells and necrosis was the pathway by which La induced cytotoxicity. Vitamin E was able to diminish the DNA strand breaks induced suggesting that oxidative stress may be involved in the genotoxic process. [PUBLICATION ABSTRACT] |
| Author | de Oliveira, Leonardo G Cabral-Neto, Januário B de Almeida, Carlos Eduardo B Paiva, Amanda V de Oliveira, Monica S Yunes, Samira N |
| Author_xml | – sequence: 1 fullname: Paiva, Amanda V – sequence: 2 fullname: de Oliveira, Monica S – sequence: 3 fullname: Yunes, Samira N – sequence: 4 fullname: de Oliveira, Leonardo G – sequence: 5 fullname: Cabral-Neto, Januário B – sequence: 6 fullname: de Almeida, Carlos Eduardo B |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18979059$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s00232-004-0718-3 10.1016/S0009-2797(03)00072-3 10.2174/156652408784221289 10.1016/S0013-9351(87)80066-X 10.1080/095530099139322 10.1016/0014-4827(88)90265-0 10.1006/abio.2001.5471 10.1016/S0891-5849(02)00967-X 10.1016/S0143-4160(96)90012-3 10.1111/j.1349-7006.2004.tb03216.x 10.1074/jbc.274.28.19792 10.1002/jcb.20303 10.1007/s10534-004-1812-9 10.1007/s001280000047 10.1016/0167-4781(94)90236-4 10.18388/abp.2000_3963 10.3748/wjg.v10.i11.1625 10.1016/S1383-5718(01)00344-8 |
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| Keywords | Cytotoxicity Lanthanum Lymphocytes Genotoxicity |
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| Snippet | Lanthanum (La) is a rare-earth metal with applications in agriculture, industry, and medicine. Since lanthanides show a broad spectrum of applications there is... The effect of lanthanum (La) on human lymphocytes viability and DNA strand break was assessed. Cellular viability, necrosis, and apoptosis were analyzed in... |
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| SubjectTerms | Agriculture Aquatic Pollution Carcinogens - toxicity Cell Survival - drug effects Cells Cytotoxicity Deoxyribonucleic acid DNA DNA Damage - drug effects Dose-Response Relationship, Drug Drug Antagonism Drug Combinations Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental Pollutants - classification Environmental Pollutants - toxicity Humans Jurkat Cells Lanthanides Lanthanum Lanthanum - classification Lanthanum - toxicity Lymphocytes Lymphocytes - drug effects Lymphocytes - pathology Metals Mutagens - toxicity Necrosis - chemically induced Oxidative stress Pollution Soil Science & Conservation Toxicology Vitamin E - pharmacology Waste Water Technology Water Management Water Pollution Control |
| Title | Effects of Lanthanum on Human Lymphocytes Viability and DNA Strand Break |
| URI | https://link.springer.com/article/10.1007/s00128-008-9596-1 https://www.ncbi.nlm.nih.gov/pubmed/18979059 https://www.proquest.com/docview/233185536 https://search.proquest.com/docview/14020191 https://search.proquest.com/docview/20653640 |
| Volume | 82 |
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