Evaluation of Cisplatin in Combination with a Biologic Response Modifier in a Murine Mammary Carcinoma Model

The purpose of this study was to determine the efficacy of intracavitary cisplatin against local regrowth and metastasis after resection of a murine mammary carcinoma and the ability of a biologic response modifier (Virulizin®) to enhance chemotherapy. C3H-HeJ mice were injected with Gollin-B tumor...

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Bibliographic Details
Published in:	Cancer investigation Vol. 20; no. 4; pp. 480 - 489
Main Authors:	Morello, Emanuela, Dernell, William S., Kuntz, Charles A., LaRue, Susan M., Lafferty, Mary, Nelson, Ann, Brekke, John H., Mallinckrodt, Craig H., Withrow, Stephen J., Manning, Mark C.
Format:	Journal Article
Language:	English
Published:	New York, NY Informa UK Ltd 2002 Taylor & Francis Informa Healthcare
Subjects:	Adenocarcinoma - drug therapy Adenocarcinoma - mortality Adenocarcinoma - pathology Adjuvants, Immunologic - therapeutic use Animals Antineoplastic agents Antineoplastic Agents - therapeutic use Bile Biological and medical sciences Carcinoma Cisplatin Cisplatin - therapeutic use Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Controlled release Delayed-Action Preparations Drug Therapy, Combination Female Immunologic Factors - therapeutic use Injections, Intraperitoneal Lactic Acid Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - mortality Mammary Neoplasms, Experimental - pathology Medical sciences Mice Mice, Inbred C3H Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Pharmacology. Drug treatments Polyesters Polymers Survival Rate Tissue Extracts Virulizin Antineoplastic agent Potentiation Recurrence Carcinoma Biological response modifier Toxicity Drug carrier Metastasis Intracavitary administration Immunotherapy Mammary gland Platinum II Complexes Immunostimulation Control release polymer Treatment efficiency Rodentia Intratumoral administration Antimetastatic agent Malignant tumor Cisplatin Mammary gland diseases Vertebrata Chemotherapy Lactic acid polymer Mammalia Treatment Mouse Animal Dosage form Combined treatment Comparative study
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