Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors

A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and ‘sheddase’ activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer. A series of novel matrix metalloproteinase inhibitors is described in which s...

Full description

Saved in:

Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 11; no. 11; pp. 1465 - 1468
Main Authors:	Baxter, Andrew D, Bhogal, Ranjev, Bird, John, Keily, John F, Manallack, David T, Montana, John G, Owen, David A, Pitt, William R, Watson, Robert J, Wills, Ruth E
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 04-06-2001 Elsevier
Subjects:	Animals Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Arthritis, Experimental - drug therapy Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Disease Models, Animal Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use General aspects Hydroxamic Acids - chemical synthesis Hydroxamic Acids - pharmacology Hydroxamic Acids - therapeutic use Matrix Metalloproteinase Inhibitors Medical sciences Melanoma, Experimental - drug therapy Mice Pharmacology. Drug treatments Antineoplastic agent Benzophenone derivatives Rat Sulfone Lung Diseases of the osteoarticular system Non peptide compound Cytotoxicity Metalloendopeptidases Inflammatory joint disease Arthritis Selectivity Structure activity relation B16-Melanoma Adjuvant Chemical synthesis Enzyme Aliphatic compound Rodentia Benzene derivatives Hydroxamic acid Enzyme inhibitor Antimetastatic agent Malignant tumor In vitro Peptidases Vertebrata Experimental disease Mammalia Mouse Animal Hydrolases
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and ‘sheddase’ activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer. A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and ‘sheddase’ activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00259-1