The μ‐opioid receptor agonist morphine, but not agonists at δ‐ or κ‐opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors

Background and purpose: Although participation of opioids in antinociception induced by cannabinoids has been documented, there is little information regarding the participation of cannabinoids in the antinociceptive mechanisms of opioids. The aim of the present study was to determine whether endoca...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 154; no. 5; pp. 1143 - 1149
Main Authors:	Da Fonseca Pacheco, D, Klein, A, De Castro Perez, A, Da Fonseca Pacheco, C M, De Francischi, J N, Duarte, I D G
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-07-2008 Nature Publishing Group
Subjects:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Analgesics, Opioid - pharmacology Animals Arachidonic Acids - pharmacology Benzamides - pharmacology Benzomorphans - pharmacology bremazocine Cannabinoid Receptor Modulators - metabolism CB1 receptor CB2 receptor Dinoprostone Disease Models, Animal Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Hyperalgesia - chemically induced Hyperalgesia - metabolism Hyperalgesia - prevention & control Indoles - pharmacology Male Morphine Morphine - pharmacology Organophosphonates - pharmacology Pain - chemically induced Pain - metabolism Pain - prevention & control Pain Measurement peripheral antinociception Piperazines - pharmacology Piperidines - pharmacology Pyrazoles - pharmacology Rats Rats, Wistar Receptor, Cannabinoid, CB1 - drug effects Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - drug effects Receptor, Cannabinoid, CB2 - metabolism Receptors, Opioid, delta - agonists Receptors, Opioid, kappa - agonists Receptors, Opioid, mu - agonists Receptors, Opioid, mu - metabolism Research Papers SNC80
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