Design and testing of a phantom and instrumented gynecological applicator based on GaN dosimeter for use in high dose rate brachytherapy quality assurance

• Published in: Medical physics (Lancaster) Vol. 43; no. 9; pp. 5240 - 5251
• Main Authors: Guiral, P., Ribouton, J., Jalade, P., Wang, R., Galvan, J.-M., Lu, G.-N., Pittet, P., Rivoire, A., Gindraux, L.
• Format: Journal Article
• Language: English
• Published: United States American Association of Physicists in Medicine 01-09-2016
• Subjects: 60 APPLIED LIFE SCIENCES; Biological material, e.g. blood, urine; Haemocytometers; biological organs; biomedical MRI; BRACHYTHERAPY; Brachytherapy - instrumentation; Brachytherapy - standards; Calibration; cancer; Clinical applications; Computed tomography; Computerised tomographs; computerised tomography; Correlation functions; DESIGN; DOSE RATES; DOSEMETERS; Dose‐volume analysis; dosimeters; dosimetry; Engineering Sciences; Equipment Design; Error analysis; Error correction; ERRORS; Female; Gallium; gallium compounds; GALLIUM NITRIDES; GaN based dosimetry; Gynecology - instrumentation; HDR brachytherapy; Humans; III‐V semiconductors; Involving electronic [emr] or nuclear [nmr] magnetic resonance, e.g. magnetic resonance imaging; MAMMARY GLANDS; PHANTOMS; Phantoms, Imaging; QUALITY ASSURANCE; Quality assurance equipment; Quality assurance in radiotherapy; Quality Assurance, Health Care; QUALITY CONTROL; QUALITY MANAGEMENT; Radiation Dosage; RADIATION PROTECTION AND DOSIMETRY; Radiation therapy; Radiometry - instrumentation; Radiotherapy Dosage; RATS; Reproducibility of Results; Scintigraphy; Silicon; TESTING; Time Factors; Transducers; Uncertainty; Vector functions; wide band gap semiconductors; quality assurance; GaN based dosimetry; HDR brachytherapy
• ISSN: 0094-2405; 2473-4209
• DOI: 10.1118/1.4961393

Purpose:
High dose rate brachytherapy (HDR-BT) is widely used to treat gynecologic, anal, prostate, head, neck, and breast cancers. These treatments are typically administered in large dose per fraction (>5 Gy) and with high-gradient-dose-distributions, with serious consequences in case of a treatment delivery error (e.g., on dwell position and dwell time). Thus, quality assurance (QA) or quality control (QC) should be systematically and independently implemented. This paper describes the design and testing of a phantom and an instrumented gynecological applicator for pretreatment QA and in vivo QC, respectively.
Methods:
The authors have designed a HDR-BT phantom equipped with four GaN-based dosimeters. The authors have also instrumented a commercial multichannel HDR-BT gynecological applicator by rigid incorporation of four GaN-based dosimeters in four channels. Specific methods based on the four GaN dosimeter responses are proposed for accurate determination of dwell time and dwell position inside phantom or applicator. The phantom and the applicator have been tested for HDR-BT QA in routine over two different periods: 29 and 15 days, respectively. Measurements in dwell position and time are compared to the treatment plan. A modified position–time gamma index is used to monitor the quality of treatment delivery.
Results:
The HDR-BT phantom and the instrumented applicator have been used to determine more than 900 dwell positions over the different testing periods. The errors between the planned and measured dwell positions are 0.11 ± 0.70 mm (1σ) and 0.01 ± 0.42 mm (1σ), with the phantom and the applicator, respectively. The dwell time errors for these positions do not exhibit significant bias, with a standard deviation of less than 100 ms for both systems. The modified position–time gamma index sets a threshold, determining whether the treatment run passes or fails. The error detectability of their systems has been evaluated through tests on intentionally introduced error protocols. With a detection threshold of 0.7 mm, the error detection rate on dwell position is 22% at 0.5 mm, 96% at 1 mm, and 100% at and beyond 1.5 mm. On dwell time with a dwell time threshold of 0.1 s, it is 90% at 0.2 s and 100% at and beyond 0.3 s.
Conclusions:
The proposed HDR-BT phantom and instrumented applicator have been tested and their main characteristics have been evaluated. These systems perform unsupervised measurements and analysis without prior treatment plan information. They allow independent verification of dwell position and time with accuracy of measurements comparable with other similar systems reported in the literature.