Analysis of free d-serine in mammals and its biological relevance

d-Serine is a unique endogenous substance enriched in the brain at the exceptionally high concentrations as a free d-amino acid in mammals throughout their life. Peripheral tissues and blood contain low or trace levels of the d-amino acid. In the nervous systems, d-serine appears to act as an intrin...

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Bibliographic Details
Published in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 879; no. 29; pp. 3169 - 3183
Main Author:	Nishikawa, Toru
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-11-2011
Subjects:	Animals biosynthesis blood Brain Brain - metabolism Brain Chemistry cell death chromatography cognition d-Serine Glutamate neurotransmission glutamic acid Glutamic Acid - metabolism Humans mammals Mental Disorders - metabolism N-methyl- d-aspartate receptor neuroglia neurons Neuropsychiatric disorders neurotransmitters pathophysiology receptors Receptors, N-Methyl-D-Aspartate - metabolism retina schizophrenia Serine - analysis Serine - metabolism Stereoisomerism Synapse–glia interaction tissues Brain AMPA BBB ALS l-glu CNS SNARE DAOA Aβ DPAG SRR PSAT THF CBT SNP ASCT2 Gly NMDA SHMT PSPH d-ser GLYT Synapse–glia interaction Glutamate neurotransmission N-methyl- d-aspartate receptor SOD1 PTSD DAO GRIP 3-PGDH Neuropsychiatric disorders GCS Dsm-1/PAPST-1 GABA Asc-1 DA d-Serine
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