New toxin from Aspergillus flavus

Two nonaflatoxin-producing isolates of Aspergillus flavus produced a new nonfluorescent nitrogen-containing metabolite that was highly toxic to 1-day-old cockerels. The oral mean lethal dose of toxin was 19 mg/kg. Chemical and physical data obtained on the purified toxin demonstrated that it was not...

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Bibliographic Details
Published in:	Applied microbiology Vol. 26; no. 5; pp. 827 - 828
Main Authors:	Kirksey, J.W, Cole, R.J
Format:	Journal Article
Language:	English
Published:	United States 01-11-1973
Subjects:	Animals Aspergillus flavus - metabolism Chickens cockerels Crystallization Culture Media Dimethylformamide Fluorescence Food Microbiology and Toxicology Lethal Dose 50 Male Mycotoxins - isolation & purification Mycotoxins - toxicity Pyridines Solubility Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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Summary:	Two nonaflatoxin-producing isolates of Aspergillus flavus produced a new nonfluorescent nitrogen-containing metabolite that was highly toxic to 1-day-old cockerels. The oral mean lethal dose of toxin was 19 mg/kg. Chemical and physical data obtained on the purified toxin demonstrated that it was not one of the previously reported metabolites of A. flavus. The common name "flavutoxin" has been assigned to the toxin.
ISSN:	0003-6919
DOI:	10.1128/AEM.26.5.827-828.1973