Application of Emerging Plant-Derived Nanoparticles as a Novel Approach for Nano-Drug Delivery Systems

• Published in: Immunological investigations Vol. 51; no. 4; pp. 1039 - 1059
• Main Authors: Sarvarian, Parisa, Samadi, Parisa, Gholipour, Elham, Shams Asenjan, Karim, Hojjat-Farsangi, Mohammad, Motavalli, Roza, Motavalli Khiavi, Farhad, Yousefi, Mehdi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 19-05-2022
• Subjects: cancer therapy; drug delivery system; exosome; Medicin och hälsovetenskap; nanovesicle; Plant-derived Nanoparticles; cancer therapy; nanovesicle; drug delivery system; Plant-derived Nanoparticles; exosome
• ISSN: 0882-0139; 1532-4311; 1532-4311
• DOI: 10.1080/08820139.2021.1891094

Nanotechnology has enabled the delivery of small molecular drugs packaged in nanosized vesicles to the target tissues. Plant-Derived Nanoparticles (PDNPs) are vesicles with natural origin and unique properties. These nanoparticles have several advantages over synthetic exosomes and liposomes. They provide bioavailability and biodistribution of therapeutic agents when delivered into different tissues. These nanoparticles can be modified according to the specificity of their functions in target tissues. When PDNPs are internalized, they can induce stem cells proliferation, reduce colitis injury, activate intrinsic and extrinsic apoptosis pathways, and inhibit tumor growth and progression. These properties make them potential drug delivery systems in targeting diseased tissues, such as inflammatory regions and different cancers.