Solvent influence on spray-dried biodegradable microspheres

Microspheres of fixed poly(D,L-lactic acid) (PDLLA) composition Resomer R104:R202H (30:70) containing 20% w/w rifampicin have been spray-dried from a range of acetonic, halogenated, and solvent mixtures thereof under constant process conditions to examine the influence of solvent selection on micros...

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Bibliographic Details
Published in:	Journal of microencapsulation Vol. 16; no. 4; pp. 453 - 474
Main Authors:	BAIN, D. F, MUNDAY, D. L, SMITHS, A
Format:	Journal Article
Language:	English
Published:	Colchester Informa UK Ltd 01-07-1999 Taylor & Francis Informa
Subjects:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biodegradable;Microsphere;Spray-dried;Rifampicin;Solvent Biodegradation, Environmental Biological and medical sciences Calorimetry, Differential Scanning Drug Carriers Drug Compounding - methods Freeze Drying General pharmacology Lactic Acid - chemistry Medical sciences Microscopy, Electron, Scanning Microspheres Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters Polymers - chemistry Regression Analysis Rifampin - chemistry Solvents - analysis Solvents - chemistry Surface Properties Biodegradation Solvent effect Differential scanning calorimetry Microsphere Pharmaceutical technology Control release polymer Spray drying Molecular interaction Drug carrier In vitro Antibiotic Lactic acid polymer Rifampicin Dosage form Active ingredient Antituberculous agent Release
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