Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs

Moxidectin, a macrocyclic lactone (ML), is a potent parasiticide widely used in veterinary medicine and currently under development for use in humans. The contribution of the lymphatic route to the intestinal absorption and transport of moxidectin to the systemic circulation was evaluated in lymph d...

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Bibliographic Details
Published in:	European journal of pharmaceutical sciences Vol. 27; no. 1; pp. 37 - 43
Main Authors:	Lespine, Anne, Chanoit, Guillaume, Bousquet-Melou, Alain, Lallemand, Elodie, Bassissi, Firas Mohamad, Alvinerie, Michel, Toutain, Pierre-Louis
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 2006 Elsevier
Subjects:	Administration, Oral Animals Anthelmintics Anthelmintics - administration & dosage Anthelmintics - blood Anthelmintics - pharmacokinetics Bioavailability Biological Transport Catheterization Chemistry, Pharmaceutical Corn Oil Corn Oil - administration & dosage Dogs Intestinal Absorption Life Sciences Lipids Lymph duct-cannulated dogs Lymphatic System Lymphatic System - metabolism Lymphatic transport Macrocyclic lactones Macrolides Macrolides - administration & dosage Macrolides - blood Macrolides - pharmacokinetics Models, Animal Moxidectin Pharmaceutical sciences Pharmacology Postprandial Period Thoracic Duct Thoracic Duct - surgery Triglycerides Triglycerides - blood Lymph duct-cannulated dogs Macrocyclic lactones Lymphatic transport Lipids Moxidectin Bioavailability Intestinal absorption Administration Catheterization Thoracic Duct Macrolides Lymphatic System Anthelmintics Triglycerides Oral Pharmaceutical Intestinal Absorption Chemistry Corn Oil Animals Biological Transport Animal Dogs Postprandial Period Models
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