Learning new tricks from an old dog: MalT of the Escherichia coli maltose system is part of a complex regulatory network

• Published in: Trends in Genetics Vol. 16; no. 9; pp. 404 - 409
• Main Authors: Boos, Winfried, Böhm, Alex
• Format: Book Review Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-09-2000; Elsevier Science
• Subjects: ABC transporter; Acetyl esterase; Bacterial Proteins - chemistry; Bacterial Proteins - metabolism; Bacteriology; Biological and medical sciences; DNA-Binding Proteins; Escherichia coli; Escherichia coli - enzymology; Escherichia coli - metabolism; Escherichia coli Proteins; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Bacterial; Genetics; mal gene; MalT protein; maltose; Maltose - metabolism; Maltotriose; Microbiology; Mlc; Protein Binding; Transcription Factors - metabolism; Transcription, Genetic; β C-S lyase; Genetics; β C-S lyase; Maltotriose; Acetyl esterase; Mlc; ABC transporter; Regulation(control); Gene; Escherichia coli; Bacteria; Molecular interaction; Activation; Review; Maltose; Gene expression; Metabolism; Enterobacteriaceae
• ISSN: 0168-9525
• DOI: 10.1016/S0168-9525(00)02086-2

The regulation of the maltose system in
Escherichia coli has traditionally been viewed as a simple positive feedback loop. Today, we know that there are cross connections to several, seemingly unrelated, metabolic pathways. MalT, the central activator of the
mal genes, is the key element in this complex regluatory network and integrates the different signals to give an appropriate transcriptional response.