Gramicidin A analogs: influence of the substitution of the tryptophans by naphthylalanines
The synthesis of 4 linear gramicidins bearing both polar and non-polar aromatic side chains is described. From the single channels data, it appears that the relative positions of these residues has little or no influence on the conductance and that this conductance is governed mainly by the number o...
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| Published in: | Biochimie Vol. 71; no. 1; p. 77 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
France
01-01-1989
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| Abstract | The synthesis of 4 linear gramicidins bearing both polar and non-polar aromatic side chains is described. From the single channels data, it appears that the relative positions of these residues has little or no influence on the conductance and that this conductance is governed mainly by the number of tryptophan residues. It is also shown that the effect of the bulkiness of the apolar aromatic side chain can be neglected. |
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| AbstractList | The synthesis of 4 linear gramicidins bearing both polar and non-polar aromatic side chains is described. From the single channels data, it appears that the relative positions of these residues has little or no influence on the conductance and that this conductance is governed mainly by the number of tryptophan residues. It is also shown that the effect of the bulkiness of the apolar aromatic side chain can be neglected. |
| Author | Daumas, P Heitz, F Ranjalahy-Rasoloarijao, L Lazaro, R |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2470419$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_bbamem_2007_05_011 crossref_primary_10_1016_S0006_3495_98_77726_4 crossref_primary_10_1021_jp304846f crossref_primary_10_1016_S0005_2736_01_00353_4 crossref_primary_10_1111_j_1751_1097_1992_tb04262_x crossref_primary_10_1002_psc_1036 crossref_primary_10_1016_j_tetasy_2012_06_020 crossref_primary_10_1007_BF01026234 crossref_primary_10_1016_0005_2736_91_90118_R crossref_primary_10_1021_bi980733k crossref_primary_10_1016_j_bbamem_2013_10_011 crossref_primary_10_1529_biophysj_107_124206 crossref_primary_10_1016_S0006_3495_02_73959_3 crossref_primary_10_1016_S0006_3495_99_77085_2 crossref_primary_10_1021_jp060688n crossref_primary_10_1529_biophysj_104_041715 crossref_primary_10_1021_la026238d crossref_primary_10_1016_0009_2614_91_90348_D crossref_primary_10_1017_S0033583500004388 crossref_primary_10_1002_cmdc_201402473 crossref_primary_10_1039_c4pp00414k |
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| Snippet | The synthesis of 4 linear gramicidins bearing both polar and non-polar aromatic side chains is described. From the single channels data, it appears that the... |
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| SubjectTerms | Alanine - analogs & derivatives Conductometry Gramicidin - chemical synthesis Lipid Bilayers Naphthalenes Spectrophotometry, Infrared Structure-Activity Relationship Tryptophan |
| Title | Gramicidin A analogs: influence of the substitution of the tryptophans by naphthylalanines |
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