Gramicidin A analogs: influence of the substitution of the tryptophans by naphthylalanines

The synthesis of 4 linear gramicidins bearing both polar and non-polar aromatic side chains is described. From the single channels data, it appears that the relative positions of these residues has little or no influence on the conductance and that this conductance is governed mainly by the number o...

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Bibliographic Details
Published in:	Biochimie Vol. 71; no. 1; p. 77
Main Authors:	Daumas, P, Heitz, F, Ranjalahy-Rasoloarijao, L, Lazaro, R
Format:	Journal Article
Language:	English
Published:	France 01-01-1989
Subjects:	Alanine - analogs & derivatives Conductometry Gramicidin - chemical synthesis Lipid Bilayers Naphthalenes Spectrophotometry, Infrared Structure-Activity Relationship Tryptophan
Online Access:	Get more information
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Summary:	The synthesis of 4 linear gramicidins bearing both polar and non-polar aromatic side chains is described. From the single channels data, it appears that the relative positions of these residues has little or no influence on the conductance and that this conductance is governed mainly by the number of tryptophan residues. It is also shown that the effect of the bulkiness of the apolar aromatic side chain can be neglected.
ISSN:	0300-9084
DOI:	10.1016/0300-9084(89)90135-1