Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene

We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists...

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Published in:	Biochemical and biophysical research communications Vol. 329; no. 4; pp. 1193 - 1199
Main Authors:	Zierhut, Barbara, Daneva, Teodora, Gartner, Wolfgang, Brunnmaier, Barbara, Mineva, Ivelina, Berggård, Tord, Wagner, Ludwig
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 22-04-2005
Subjects:	Alternative Splicing - genetics Amino Acid Sequence Antibodies - immunology Biologi Biological Sciences Calcium - metabolism Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cloning, Molecular DNA, Complementary - genetics EF-hand calcium binding protein Escherichia coli - genetics Humans Molecular Sequence Data Natural Sciences Naturvetenskap RNA editing RNA, Messenger - genetics RNA, Messenger - metabolism Secretagogin Secretagogin-R22 Secretagogins Sequence Alignment Setagin Transcription, Genetic - genetics Secretagogin RNA editing Secretagogin-R22 Setagin EF-hand calcium binding protein
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Abstract	We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells.
AbstractList	We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells. We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells. (c) 2005 Elsevier Inc. All rights reserved.
Author	Berggård, Tord Mineva, Ivelina Zierhut, Barbara Gartner, Wolfgang Brunnmaier, Barbara Wagner, Ludwig Daneva, Teodora
Author_xml	– sequence: 1 givenname: Barbara surname: Zierhut fullname: Zierhut, Barbara organization: Department of Medicine III, University of Vienna, Vienna A-1090, Austria – sequence: 2 givenname: Teodora surname: Daneva fullname: Daneva, Teodora organization: Department of Medicine III, University of Vienna, Vienna A-1090, Austria – sequence: 3 givenname: Wolfgang surname: Gartner fullname: Gartner, Wolfgang organization: Department of Medicine III, University of Vienna, Vienna A-1090, Austria – sequence: 4 givenname: Barbara surname: Brunnmaier fullname: Brunnmaier, Barbara organization: Department of Medicine III, University of Vienna, Vienna A-1090, Austria – sequence: 5 givenname: Ivelina surname: Mineva fullname: Mineva, Ivelina organization: Department of Medicine III, University of Vienna, Vienna A-1090, Austria – sequence: 6 givenname: Tord surname: Berggård fullname: Berggård, Tord organization: Department of Biophysical Chemistry, Lund University, SE-221 00 Lund, Sweden – sequence: 7 givenname: Ludwig surname: Wagner fullname: Wagner, Ludwig email: Ludwig.Wagner@meduniwien.ac.at organization: Department of Medicine III, University of Vienna, Vienna A-1090, Austria
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Biol. (Noisy-le-grand) contributor: fullname: Desiderio
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Snippet	We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is...
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SubjectTerms	Alternative Splicing - genetics Amino Acid Sequence Antibodies - immunology Biologi Biological Sciences Calcium - metabolism Calcium-Binding Proteins - chemistry Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cloning, Molecular DNA, Complementary - genetics EF-hand calcium binding protein Escherichia coli - genetics Humans Molecular Sequence Data Natural Sciences Naturvetenskap RNA editing RNA, Messenger - genetics RNA, Messenger - metabolism Secretagogin Secretagogin-R22 Secretagogins Sequence Alignment Setagin Transcription, Genetic - genetics
Title	Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene
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