Insulin Promoter Factor-1 Mutations and Diabetes in Trinidad: Identification of a Novel Diabetes-Associated Mutation (E224K) in an Indo-Trinidadian Family

This study investigated the prevalence of insulin promoter factor-1(IPF-1) mutations in familial early-onset diabetes mellitus in Trinidad. We screened 264 unrelated subjects with type 2 diabetes diagnosed before 40 yr of age and a family history of diabetes for mutations in the minimal promoter and...

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Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 89; no. 2; pp. 971 - 978
Main Authors:	Cockburn, Brian N., Bermano, Giovanna, Boodram, Laura-Lee G., Teelucksingh, Surujpal, Tsuchiya, Takafumi, Mahabir, Deepak, Allan, Andrew B., Stein, Roland, Docherty, Kevin, Bell, Graeme I.
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Endocrine Society 01-02-2004 Copyright by The Endocrine Society
Subjects:	Adult Africa - ethnology Aged Biological and medical sciences Cell Line Diabetes Mellitus - genetics Endocrinopathies Female Founder Effect Fundamental and applied biological sciences. Psychology Glucose Intolerance - genetics Glucose Tolerance Test Glutamic Acid - genetics Haplotypes HeLa Cells Homeodomain Proteins Humans India - ethnology Lysine - genetics Male Medical sciences Middle Aged Mutation Mutation, Missense Pedigree Trans-Activators - genetics Trans-Activators - metabolism Transcriptional Activation Trinidad and Tobago Vertebrates: endocrinology Trinidad and Tobago Africa India Endocrinopathy Pancreatic hormone Family study Transcription promoter Diabetes mellitus Identification Mutation Insulin Endocrinology
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