RAF1–MEK/ERK pathway‐dependent ARL4C expression promotes ameloblastoma cell proliferation and osteoclast formation

Ameloblastoma is an odontogenic neoplasm characterized by slow intraosseous growth with progressive jaw resorption. Recent reports have revealed that ameloblastoma harbours an oncogenic BRAFV600E mutation with mitogen‐activated protein kinase (MAPK) pathway activation and described cases of amelobla...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of pathology Vol. 256; no. 1; pp. 119 - 133
Main Authors:	Fujii, Shinsuke, Ishibashi, Takuma, Kokura, Megumi, Fujimoto, Tatsufumi, Matsumoto, Shinji, Shidara, Satsuki, Kurppa, Kari J, Pape, Judith, Caton, Javier, Morgan, Peter R, Heikinheimo, Kristiina, Kikuchi, Akira, Jimi, Eijiro, Kiyoshima, Tamotsu
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-01-2022 Wiley Subscription Services, Inc
Subjects:	ADP-Ribosylation Factors - metabolism Ameloblastoma Ameloblastoma - genetics Ameloblastoma - metabolism ARL4C Bone marrow Bone resorption BRAFV600E Catenin Cell growth Cell proliferation Cell Proliferation - genetics Cell Proliferation - physiology Cell Transformation, Neoplastic - genetics Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Female Gene Expression Regulation, Neoplastic - genetics Humans Jaw Kinases Male MAP kinase MAP Kinase Signaling System - physiology Metabolic pathways Mitogen-Activated Protein Kinase Kinases - metabolism Morphogenesis Mutation Neoplasia Osteoblasts osteoclast formation Osteoclasts - metabolism Osteoclasts - pathology proliferation Protein kinase Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Raf protein RAF1 Ribosylation Signal transduction siRNA TRANCE protein Tumorigenesis Tumors Wnt protein Wnt Signaling Pathway - genetics ARL4C BRAFV600E osteoclast formation proliferation RAF1 ameloblastoma
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!