A quantitative study of the facial nerve in mice prenatally exposed to ethanol
ABSTRACT Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were killed at 56 days of age and the motor root of their facial nerve was examined histologically and morphometrically. The cross‐sectional area of...
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| Published in: | Congenital anomalies Vol. 43; no. 1; pp. 41 - 45 |
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01-03-2003
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| Abstract | ABSTRACT Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were killed at 56 days of age and the motor root of their facial nerve was examined histologically and morphometrically. The cross‐sectional area of the facial nerve of mice prenatally exposed to ethanol was significantly smaller than that of the control mice. There was no significant difference in the total number of myelinated axons or the mean axonal diameter between control and ethanol‐exposed mice, but the mean diameter of myelinated fibers (axon + myelin sheath) and the thickness of myelin sheath were significantly decreased in the treated group. These results suggest that prenatal exposure to ethanol disturbs myelination of the motor root of the facial nerve and may cause permanent neurological effects. |
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| AbstractList | ABSTRACT
Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were killed at 56 days of age and the motor root of their facial nerve was examined histologically and morphometrically. The cross‐sectional area of the facial nerve of mice prenatally exposed to ethanol was significantly smaller than that of the control mice. There was no significant difference in the total number of myelinated axons or the mean axonal diameter between control and ethanol‐exposed mice, but the mean diameter of myelinated fibers (axon + myelin sheath) and the thickness of myelin sheath were significantly decreased in the treated group. These results suggest that prenatal exposure to ethanol disturbs myelination of the motor root of the facial nerve and may cause permanent neurological effects. Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were killed at 56 days of age and the motor root of their facial nerve was examined histologically and morphometrically. The cross-sectional area of the facial nerve of mice prenatally exposed to ethanol was significantly smaller than that of the control mice. There was no significant difference in the total number of myelinated axons or the mean axonal diameter between control and ethanol-exposed mice, but the mean diameter of myelinated fibers (axon + myelin sheath) and the thickness of myelin sheath were significantly decreased in the treated group. These results suggest that prenatal exposure to ethanol disturbs myelination of the motor root of the facial nerve and may cause permanent neurological effects. ABSTRACT Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were killed at 56 days of age and the motor root of their facial nerve was examined histologically and morphometrically. The cross‐sectional area of the facial nerve of mice prenatally exposed to ethanol was significantly smaller than that of the control mice. There was no significant difference in the total number of myelinated axons or the mean axonal diameter between control and ethanol‐exposed mice, but the mean diameter of myelinated fibers (axon + myelin sheath) and the thickness of myelin sheath were significantly decreased in the treated group. These results suggest that prenatal exposure to ethanol disturbs myelination of the motor root of the facial nerve and may cause permanent neurological effects. |
| Author | Komatsu, Suguru Sasaki, Yasuo Shiota, Kohei |
| Author_xml | – sequence: 1 givenname: Suguru surname: Komatsu fullname: Komatsu, Suguru email: komatsu@cac.med.kyoto-u.ac.jp organization: Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan – sequence: 2 givenname: Yasuo surname: Sasaki fullname: Sasaki, Yasuo organization: Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan – sequence: 3 givenname: Kohei surname: Shiota fullname: Shiota, Kohei organization: Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan |
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10.1002/(SICI)1097-4547(19990515)56:4<334::AID-JNR2>3.0.CO;2-# – ident: e_1_2_1_16_1 doi: 10.1016/0736-5748(92)90059-9 – volume: 138 start-page: 207 year: 1984 ident: e_1_2_1_5_1 article-title: Abnormal development of the facial nerve nucleus in reeler mutant mice publication-title: J Anat contributor: fullname: Goffinet AM – ident: e_1_2_1_13_1 doi: 10.1007/BF02624103 – volume: 187 start-page: 739 year: 1995 ident: e_1_2_1_14_1 article-title: Loss of myelinated axons is specific to the central nervous system in a mouse model of the fetal alcohol syndrome publication-title: J Anat contributor: fullname: Parson SH – ident: e_1_2_1_12_1 doi: 10.1159/000112154 – ident: e_1_2_1_19_1 doi: 10.1002/aja.1001660303 – ident: e_1_2_1_3_1 doi: 10.1111/j.1530-0277.1989.tb00375.x – ident: e_1_2_1_9_1 doi: 10.1016/S0140-6736(73)91092-1 – volume: 13 start-page: 7 year: 2001 ident: e_1_2_1_6_1 article-title: Craniofacial alterations in adult rats after acute prenatal alcohol exposure publication-title: J Ayub Medical Coll Abbottabad contributor: fullname: Ismail M. – ident: e_1_2_1_11_1 doi: 10.1037/0894-4105.12.1.146 – ident: e_1_2_1_7_1 doi: 10.1016/0892-0362(94)00063-J – ident: e_1_2_1_8_1 doi: 10.1016/S0166-2236(98)01391-5 – ident: e_1_2_1_2_1 doi: 10.1016/S0022-3476(96)70187-7 – ident: e_1_2_1_15_1 doi: 10.1016/0014-4886(89)90190-8 – ident: e_1_2_1_10_1 doi: 10.1016/S0140-6736(73)91291-9 |
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| Snippet | ABSTRACT Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were... Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were killed at 56... ABSTRACT Pregnant ICR mice were given 20% ethanol intraperitoneally twice on day 13 of gestation and allowed to give birth to offspring. The offspring were... |
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| SubjectTerms | Animals Axons - drug effects Disease Models, Animal ethanol Ethanol - adverse effects facial nerve Facial Nerve - drug effects Female Fetal Alcohol Spectrum Disorders - etiology fetal alcohol syndrome Maternal Exposure Mice Mice, Inbred ICR Microscopy, Electron mouse myelination Nerve Fibers, Myelinated - drug effects Pregnancy Pregnancy, Animal Time Factors |
| Title | A quantitative study of the facial nerve in mice prenatally exposed to ethanol |
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