A Case with Multiple Pathologies in the Pancreatic Head

• Published in: Biomedicines Vol. 12; no. 8; p. 1762
• Main Authors: Vujasinovic, Miroslav, Ghazi, Sam, Kartalis, Nikolaos, Gustafsson Liljefors, Maria, D'Souza, Melroy A, Ghorbani, Poya, Löhr, J-Matthias
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05-08-2024; MDPI
• Subjects: Abdomen; Adenocarcinoma; autoimmune pancreatitis; Bile ducts; Biopsy; Cancer; Case Report; Comorbidity; Cysts; Diagnosis; Endoscopy; follicular pancreatitis; Immunoglobulin G; IPMN; Kidney stones; Kidneys; Lesions; Medicin och hälsovetenskap; Outpatient care facilities; Pancreas; Pancreatic cancer; pancreatic ductal adenocarcinoma; Pancreatitis; paraduodenal pancreatitis; Patients; Phosphatase; Small intestine; Veins & arteries; Sweden; autoimmune pancreatitis; IPMN; follicular pancreatitis; paraduodenal pancreatitis; pancreatic ductal adenocarcinoma
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines12081762

Autoimmune pancreatitis (AIP) type 1, paraduodenal (groove) pancreatitis, and follicular pancreatitis are rare clinical entities whose diagnosis may be challenging, given the potential imaging overlap with pancreatic cancer.
We performed a retrospective analysis of the medical chart of a patient with multiple pancreas pathologies.
We present a case with multiple pancreas pathologies, including a poorly differentiated ductal adenocarcinoma of pancreatobiliary type, an intraductal papillary mucinous lesion (pre-existing lesion of IPMN type), and an inflammatory process with complex features, in which paraduodenal (groove) pancreatitis, follicular pancreatitis, and IgG4-related pancreatitis (AIP type 1) were also present.
The diagnosis of AIP and paraduodenal pancreatitis is not always straightforward, and in some cases, it is not easy to differentiate them from pancreatic cancer. Surgery should be considered in patients when a suspicion of malignant/premalignant lesions cannot be excluded after a complete diagnostic work-up.