Heme oxygenase-1 system and gastrointestinal tumors

• Published in: World journal of gastroenterology : WJG Vol. 16; no. 21; pp. 2633 - 2637
• Main Authors: Zhu, Xiao, Fan, Wen-Guo, Li, Dong-Pei, Lin, Marie C M, Kung, Hsiangfu
• Format: Journal Article
• Language: English
• Published: United States Institute of Oncology,Affiliated Tumor Hospital of Guangzhou Medical College,Guangzhou 510095,Guangdong Province,China%Guanghua School of Stomatology,Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China%Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China%The Brain Tumor Center and Neurosurgery Division,Prince of Wales Hospital,The Chinese University of Hong Kong,Shatin,Hong Kong,China%Li Ka Shing Institute of Medical Sciences,the Chinese University of Hong Kong,Shatin,Hong Kong,China 07-06-2010; Baishideng
• Subjects: Enzyme Induction; Gastrointestinal Neoplasms - enzymology; Gastrointestinal Neoplasms - pathology; Heme - metabolism; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - metabolism; Humans; Isoenzymes - genetics; Isoenzymes - metabolism; Polymorphism, Genetic; Promoter Regions, Genetic; Review; Gastrointestinal tumors; Heme oxygenase-1
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v16.i21.2633

Heme oxygenase-1(HO-1) system catabolizes heme into three products:carbon monoxide,biliverdin/bilirubin and free iron.It is involved in many physiological and pathophysiological processes.A great deal of data has demonstrated the roles of HO-1 in the formation,growth and metastasis of tumors.The interest in this system by investigators involved in gastrointestinal tumors is fairly recent,and few papers on HO-1 have touched upon this subject.This review focuses on the current understanding of the physiologic...