Comparison of Formation of Capsule Among Different Breast Silicone Implants

• Published in: In vivo (Athens) Vol. 36; no. 6; pp. 2756 - 2766
• Main Authors: Zhang, Xin Rui, Chien, Pham Ngoc, Trinh, Xuan-Tung, Nam, Sun-Young, Heo, Chan-Yeong
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01-11-2022
• Subjects: Animals; Breast Implantation; Breast Implants - adverse effects; Collagen; Contracture - surgery; Inflammation - surgery; Interleukin-8; Rats; Silicone Gels - adverse effects; Vimentin; surface texture; Silicone implants; anaplastic large cell lymphoma; bacterial biofilms; capsular contracture
• ISSN: 0258-851X; 1791-7549
• DOI: 10.21873/invivo.13012

Silicone implants are widely used biomaterials in surgeries owing to their physiological inertness and low toxicity. However, capsular contracture is a severe complication caused by the insertion of breast implants, which can endanger the health of patients. In this study, twelve different silicone breast implants were tested to determine which could lead to a lower incidence of capsular contracture.
For in vivo experiments, these silicone implants were implanted into 60 rats (i.e., five implants per rat). The implants were explanted eight weeks after the operation. Samples were analyzed and measured by using hematoxylin and eosin staining, Masson's trichrome staining, and immunofluorescence staining methods. We compared twelve samples for their differences in the thickness of capsular formation, number of inflammatory cells, collagen expression, fibroblast intensity (i.e., Vimentin and α-SMA), and inflammatory cytokines (i.e., IL-8, CD68, MCP-1, and F4/80).
Different surface textures of breast implants gave different effects on capsular thickness, collagen formation, fibroblast formation, and potential inflammation. Samples that had smooth textures such as SEBBIN, HANS, and Mentor showed higher collagen formation than other samples. SEBBIN Texture, Motiva Micro, HANS Smooth I, and HANS Micro exhibited higher fibroblast formation (i.e., α-SMA, Vimentin). SEBBIN Smooth and samples in HANS group displayed lower expression of inflammation cytokines (IL-8, CD68, MCP-1, and F4/80).
These findings provide preliminary reports on the surface texture effect and support a selection of breast silicone implants in breast reconstruction to avoid the formation of capsular contracture after implantation.