Influence of ionizing radiation on proliferation, c-myc expression and the induction of apoptotic cell death in two breast tumour cell lines differing in p53 status

Purpose : To determine the capacity of ionizing radiation to inhibit proliferation, to suppress c- myc expression and to induce apoptotic cell death in the p53 wild-type MCF-7 cell line and the p53 mutated MDA-MB231 cell line. Materials and methods : Growth inhibition and cell killing were determine...

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Bibliographic Details
Published in:	International journal of radiation biology Vol. 72; no. 5; pp. 547 - 559
Main Authors:	WATSON, N. C, DI, Y.-M, ORR, M. S, FORNARI, F. A, RANDOLPH, J. K, MAGNET, K. J, JAIN, P. T, GEVIRTZ, D. A
Format:	Journal Article
Language:	English
Published:	London Informa UK Ltd 01-11-1997 Taylor & Francis
Subjects:	Apoptosis - radiation effects Biological and medical sciences Biological effects of radiation Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Division - radiation effects DNA Damage Female Fundamental and applied biological sciences. Psychology G1 Phase Genes, myc - radiation effects Humans Radiocontamination Space life sciences Tissues, organs and organisms biophysics Tumor Cells, Cultured Tumor Suppressor Protein p53 - analysis Ionizing radiation DNA Established cell line Radiation injury Tumor Gene expression Apoptosis
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