The flame retardants tetrabromobisphenol A and tetrabromobisphenol A–bisallylether suppress the induction of interleukin-2 receptor α chain (CD25) in murine splenocytes

Polybrominated flame retardants (PBF) are frequently used additives in electronical equipment. They are ubiquitous environmental contaminants which bioaccumulate with several health effects for humans and the environment. This study investigated immunotoxic effects of the PBF tetrabromobisphenol A (...

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Bibliographic Details
Published in:	Toxicology (Amsterdam) Vol. 184; no. 1; pp. 11 - 22
Main Authors:	Pullen, Sabine, Boecker, Ronald, Tiegs, Gisa
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 14-02-2003 Amsterdam Elsevier Science
Subjects:	Ah-receptor Animals Biological and medical sciences Cell Separation Cell Survival - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Cytochrome P-450 CYP1A1 - biosynthesis Cytochrome P450 1A1 Cytokines - metabolism Enzyme Induction - drug effects Enzyme-Linked Immunosorbent Assay Female Flame Retardants - toxicity Hepatocytes - drug effects IL-2 receptor α chain (CD25) Immunohistochemistry Immunotoxicity Indicators and Reagents Interleukin-2 - biosynthesis Laser scanning cytometry Medical sciences Mice Mice, Inbred C57BL Microscopy, Confocal Polybrominated Biphenyls - toxicity Polybrominated flame retardants Receptors, Interleukin-2 - biosynthesis Solutions Spleen - cytology Spleen - drug effects Spleen - metabolism Tetrazolium Salts Thiazoles Toxicology Various organic compounds PAH, polychlorinated aromatic hydrocarbons PCB77, 3,4,3′,4′-tetrachlorobiphenyl Immunotoxicity TBBP A-PE, tetrabromobisphenol A-bis-(2,3-dibromopropylether) Polybrominated flame retardants PBF, polybrominated flame retardants TBBP A, tetrabromobisphenol A Laser scanning cytometry CYP 1A1, cytochrome P450 1A1 MTT, 3(4,5-dimethyl-thiazoyl-2-yl)2,5-diphenyl-tetrazolium bromide IL-2 receptor α chain (CD25) Cytochrome P450 1A1 Con A, concanavalin A TBBP A-AE, tetrabromobisphenol A-bisallylether EROD, ethoxyresorufin- o-deethylase TCDD, 2,3,7,8-tetrachlorodibenzo- p-dioxin TBP, 2,4,6-tribromophenol DBDE, decabromodiphenylether MC, 3-methylcholanthrene Ah receptor, aryl hydrocarbon receptor CD25, interleukin-2 receptor α chain Ah-receptor Immunopathology Toxicity Cytochrome P450 Cytokine Rodentia Flame retardant Splenocyte In vitro Ah receptor Vertebrata Mammalia Hepatocyte Interleukin 2 Mouse Animal Alpha-Peptide chain Bromine Organic compounds IL-2 receptor 7 chain (CD25) Mechanism of action
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