Arachidonate 5 lipoxygenase expression in papillary thyroid carcinoma promotes invasion via MMP-9 induction

Arachidonate 5‐lipoxygenase (ALOX5) expression and activity has been implicated in tumor pathogenesis, yet its role in papillary thyroid carcinoma (PTC) has not been characterized. ALOX5 protein and mRNA were upregulated in PTC compared to matched, normal thyroid tissue, and ALOX5 expression correla...

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Bibliographic Details
Published in:	Journal of cellular biochemistry Vol. 113; no. 6; pp. 1998 - 2008
Main Authors:	Kummer, Nicolas T., Nowicki, Theodore S., Azzi, Jean P., Reyes, Ismael, Iacob, Codrin, Xie, Suqing, Swati, Ismatun, Darzynkiewicz, Zbigniew, Gotlinger, Katherine H., Suslina, Nina, Schantz, Stimson, Tiwari, Raj K., Geliebter, Jan
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-06-2012
Subjects:	5-HETE Adult Aged ARACHIDONATE 5-LIPOXYGENASE Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Biomarkers, Tumor Carcinoma Carcinoma, Papillary Cell Cycle Cell Line, Tumor Cell Movement Cell Proliferation EXTRACELLULAR MATRIX Extracellular Matrix - metabolism Female Humans Hydroxyeicosatetraenoic Acids - metabolism Hydroxyeicosatetraenoic Acids - pharmacology Lipoxygenase Inhibitors - pharmacology Male Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors MATRIX METALLOPROTEINASE-9 Middle Aged Neoplasm Invasiveness PAPILLARY THYROID CARCINOMA RNA, Messenger - genetics RNA, Messenger - metabolism Thyroid Cancer, Papillary Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology TUMOR INVASION Young Adult
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