Precision transplant pathology
Transplant pathology contributes substantially to personalized treatment of organ allograft recipients. Rapidly advancing next-generation human leukocyte antigen (HLA) sequencing and pathology are enhancing the abilities to improve donor/recipient matching and allograft monitoring. The present revie...
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| Published in: | Current opinion in organ transplantation Vol. 25; no. 4; pp. 412 - 419 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-08-2020
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| Abstract | Transplant pathology contributes substantially to personalized treatment of organ allograft recipients. Rapidly advancing next-generation human leukocyte antigen (HLA) sequencing and pathology are enhancing the abilities to improve donor/recipient matching and allograft monitoring.
The present review summarizes the workflow of a prototypical patient through a pathology practice, highlighting histocompatibility assessment and pathologic review of tissues as areas that are evolving to incorporate next-generation technologies while emphasizing critical needs of the field.
Successful organ transplantation starts with the most precise pratical donor-recipient histocompatibility matching. Next-generation sequencing provides the highest resolution donor-recipient matching and enables eplet mismatch scores and more precise monitoring of donor-specific antibodies (DSAs) that may arise after transplant. Multiplex labeling combined with hand-crafted machine learning is transforming traditional histopathology. The combination of traditional blood/body fluid laboratory tests, eplet and DSA analysis, traditional and next-generation histopathology, and -omics-based platforms enables risk stratification and identification of early subclinical molecular-based changes that precede a decline in allograft function. Needs include software integration of data derived from diverse platforms that can render the most accurate assessment of allograft health and needs for immunosuppression adjustments. |
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| AbstractList | PURPOSE OF REVIEWTransplant pathology contributes substantially to personalized treatment of organ allograft recipients. Rapidly advancing next-generation human leukocyte antigen (HLA) sequencing and pathology are enhancing the abilities to improve donor/recipient matching and allograft monitoring.RECENT FINDINGSThe present review summarizes the workflow of a prototypical patient through a pathology practice, highlighting histocompatibility assessment and pathologic review of tissues as areas that are evolving to incorporate next-generation technologies while emphasizing critical needs of the field.SUMMARYSuccessful organ transplantation starts with the most precise pratical donor-recipient histocompatibility matching. Next-generation sequencing provides the highest resolution donor-recipient matching and enables eplet mismatch scores and more precise monitoring of donor-specific antibodies (DSAs) that may arise after transplant. Multiplex labeling combined with hand-crafted machine learning is transforming traditional histopathology. The combination of traditional blood/body fluid laboratory tests, eplet and DSA analysis, traditional and next-generation histopathology, and -omics-based platforms enables risk stratification and identification of early subclinical molecular-based changes that precede a decline in allograft function. Needs include software integration of data derived from diverse platforms that can render the most accurate assessment of allograft health and needs for immunosuppression adjustments. Transplant pathology contributes substantially to personalized treatment of organ allograft recipients. Rapidly advancing next-generation human leukocyte antigen (HLA) sequencing and pathology are enhancing the abilities to improve donor/recipient matching and allograft monitoring. The present review summarizes the workflow of a prototypical patient through a pathology practice, highlighting histocompatibility assessment and pathologic review of tissues as areas that are evolving to incorporate next-generation technologies while emphasizing critical needs of the field. Successful organ transplantation starts with the most precise pratical donor-recipient histocompatibility matching. Next-generation sequencing provides the highest resolution donor-recipient matching and enables eplet mismatch scores and more precise monitoring of donor-specific antibodies (DSAs) that may arise after transplant. Multiplex labeling combined with hand-crafted machine learning is transforming traditional histopathology. The combination of traditional blood/body fluid laboratory tests, eplet and DSA analysis, traditional and next-generation histopathology, and -omics-based platforms enables risk stratification and identification of early subclinical molecular-based changes that precede a decline in allograft function. Needs include software integration of data derived from diverse platforms that can render the most accurate assessment of allograft health and needs for immunosuppression adjustments. |
| Author | Wood-Trageser, Michelle A. Demetris, Anthony J. Randhawa, Parmjeet Zeevi, Adriana Lesniak, Drew Xu, Qinyong |
| AuthorAffiliation | 2 Division of Liver and Transplantation Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA 1 Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213 USA |
| AuthorAffiliation_xml | – name: 2 Division of Liver and Transplantation Pathology, Department of Pathology, University of Pittsburgh, PA 15213, USA – name: 1 Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213 USA |
| Author_xml | – sequence: 1 givenname: Michelle A. surname: Wood-Trageser fullname: Wood-Trageser, Michelle A. organization: Thomas E. Starzl Transplantation Institute, University of Pittsburgh – sequence: 2 givenname: Qinyong surname: Xu fullname: Xu, Qinyong organization: Thomas E. Starzl Transplantation Institute, University of Pittsburgh – sequence: 3 givenname: Adriana surname: Zeevi fullname: Zeevi, Adriana organization: Thomas E. Starzl Transplantation Institute, University of Pittsburgh – sequence: 4 givenname: Parmjeet surname: Randhawa fullname: Randhawa, Parmjeet organization: Thomas E. Starzl Transplantation Institute, University of Pittsburgh – sequence: 5 givenname: Drew surname: Lesniak fullname: Lesniak, Drew organization: Thomas E. Starzl Transplantation Institute, University of Pittsburgh – sequence: 6 givenname: Anthony J. surname: Demetris fullname: Demetris, Anthony J. organization: Thomas E. Starzl Transplantation Institute, University of Pittsburgh |
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| Cites_doi | 10.1097/MOT.0000000000000714 10.1097/MOT.0000000000000540 10.4103/jpi.jpi_27_19 10.1097/TP.0000000000001667 10.1111/ajt.15177 10.1016/j.jprot.2016.03.025 10.1111/ajt.12079 10.1007/978-1-4939-9773-2_22 10.1093/nargab/lqz010 10.1007/978-1-4939-9773-2_30 10.1097/TP.0000000000002568 10.1056/NEJMp1500523 10.1016/j.tips.2019.10.009 10.1111/ajt.14329 10.1681/ASN.2017030287 10.1111/ajt.14233 10.1007/978-1-4939-9773-2_21 10.1007/978-1-4939-9773-2_29 10.4103/jpi.jpi_82_18 10.1046/j.1600-6143.2004.00603.x 10.1016/j.transproceed.2019.04.054 10.1007/978-1-4939-9773-2_24 10.1186/s12882-019-1670-x 10.1007/978-1-4939-9773-2_26 10.1007/978-1-4939-9773-2_28 10.1007/978-1-4939-9773-2_25 10.1681/ASN.2019020144 10.1111/ajt.13376 10.1002/prca.201900036 10.1038/s41586-018-0047-9 10.1111/ajt.15258 10.15252/msb.20167144 10.1111/tan.12390 10.1097/MOT.0b013e32832ca2b8 10.1007/978-1-4939-9773-2_23 10.1097/TXD.0000000000000650 10.1097/TP.0000000000002656 10.1038/s41592-018-0261-2 |
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| References | Eng (R36-20230918) 2020; 2055 Ziv (R42-20230918) 2020; 2055 Halloran (R19-20230918) 2017; 17 Wiebe (R14-20230918) 2019; 19 Palmisano (R43-20230918) 2020; 2055 Madill-Thomsen (R22-20230918) 2017; 17 Aeffner (R45-20230918) 2019; 10 Patel (R33-20230918) 2020; 2055 Madbouly (R16-20230918) 2014; 84 Edfors (R26-20230918) 2016; 12 Wood-Trageser (R17-20230918) 2019; 103 Drachenberg (R20-20230918) 2004; 4 Huang (R15-20230918) 2019; 19 Wiebe (R9-20230918) 2018; 23 Collins (R2-20230918) 2015; 372 Wehmeier (R28-20230918) 2017; 3 Ruelcke (R24-20230918) 2016; 149 Girolami (R38-20230918) 2019; 10 Falk (R41-20230918) 2019; 16 Kriss (R18-20230918) 2019; 103 Reeve (R21-20230918) 2013; 13 Wiebe (R7-20230918) 2017; 28 Wiebe (R8-20230918) 2020; 25 Akturk (R35-20230918) 2020; 2055 Hosseini (R40-20230918) 2018 Duquesnoy (R13-20230918) 2017; 101 Rüger (R5-20230918) 2020; 41 Abudhaise (R32-20230918) 2019; 51 Wegler (R25-20230918) 2020; 2 Song (R27-20230918) 2020 Duquesnoy (R12-20230918) 2009; 14 Beechem (R23-20230918) 2020; 2055 Francisco-Cruz (R34-20230918) 2020; 2055 Nasralla (R4-20230918) 2018; 557 Duquesnoy (R10-20230918) 2015; 15 Hermsen (R39-20230918) 2019; 30 Manesse (R37-20230918) 2020; 2055 Naderi (R6-20230918) 2020; 21 Thorsson (R44-20230918) 2020; 2055 |
| References_xml | – volume: 25 start-page: 8 year: 2020 ident: R8-20230918 article-title: Human leukocyte antigen molecular mismatch to risk stratify kidney transplant recipients publication-title: Curr Opin Organ Transplant doi: 10.1097/MOT.0000000000000714 contributor: fullname: Wiebe – volume: 23 start-page: 500 year: 2018 ident: R9-20230918 article-title: Human leukocyte antigen mismatch and precision medicine in transplantation publication-title: Curr Opin Organ Transplant doi: 10.1097/MOT.0000000000000540 contributor: fullname: Wiebe – volume: 10 start-page: 21 year: 2019 ident: R38-20230918 article-title: The landscape of digital pathology in transplantation: from the beginning to the virtual E-slide publication-title: J Pathol Inform doi: 10.4103/jpi.jpi_27_19 contributor: fullname: Girolami – volume: 101 start-page: 1755 year: 2017 ident: R13-20230918 article-title: Are we ready for epitope-based HLA matching in clinical organ transplantation? publication-title: Transplantation doi: 10.1097/TP.0000000000001667 contributor: fullname: Duquesnoy – volume: 19 start-page: 1708 year: 2019 ident: R14-20230918 article-title: HLA-DR/DQ molecular mismatch: a prognostic biomarker for primary alloimmunity publication-title: Am J Transplant doi: 10.1111/ajt.15177 contributor: fullname: Wiebe – volume: 149 start-page: 3 year: 2016 ident: R24-20230918 article-title: Reducing the cost of semi-automated in-gel tryptic digestion and GeLC sample preparation for high-throughput proteomics publication-title: J Proteomics doi: 10.1016/j.jprot.2016.03.025 contributor: fullname: Ruelcke – volume: 13 start-page: 645 year: 2013 ident: R21-20230918 article-title: Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies publication-title: Am J Transplant doi: 10.1111/ajt.12079 contributor: fullname: Reeve – volume: 2055 start-page: 467 year: 2020 ident: R34-20230918 article-title: Multiplex immunofluorescence assays publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_22 contributor: fullname: Francisco-Cruz – volume: 2 start-page: lqz010 year: 2020 ident: R25-20230918 article-title: Global variability analysis of mRNA and protein concentrations across and within human tissues publication-title: NAR Genom Bioinform doi: 10.1093/nargab/lqz010 contributor: fullname: Wegler – volume: 2055 start-page: 679 year: 2020 ident: R44-20230918 article-title: Multiplatform integrative analysis of immunogenomic data for biomarker discovery publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_30 contributor: fullname: Thorsson – volume: 103 start-page: 668 year: 2019 ident: R18-20230918 article-title: Functional microbiomics in liver transplantation: identifying novel targets for improving allograft outcomes publication-title: Transplantation doi: 10.1097/TP.0000000000002568 contributor: fullname: Kriss – volume: 372 start-page: 793 year: 2015 ident: R2-20230918 article-title: A new initiative on precision medicine publication-title: N Engl J Med doi: 10.1056/NEJMp1500523 contributor: fullname: Collins – volume: 41 start-page: 27 year: 2020 ident: R5-20230918 article-title: Oligonucleotides to the (Gene) Rescue: FDA Approvals 2017-2019 publication-title: Trends Pharmacol Sci doi: 10.1016/j.tips.2019.10.009 contributor: fullname: Rüger – volume: 17 start-page: 2851 year: 2017 ident: R19-20230918 article-title: Real time central assessment of kidney transplant indication biopsies by microarrays: the INTERCOMEX study publication-title: Am J Transplant doi: 10.1111/ajt.14329 contributor: fullname: Halloran – volume: 28 start-page: 3353 year: 2017 ident: R7-20230918 article-title: Class II eplet mismatch modulates tacrolimus trough levels required to prevent donor-specific antibody development publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2017030287 contributor: fullname: Wiebe – volume: 17 start-page: 2117 year: 2017 ident: R22-20230918 article-title: The effect of cortex/medulla proportions on molecular diagnoses in kidney transplant biopsies: rejection and injury can be assessed in medulla publication-title: Am J Transplant doi: 10.1111/ajt.14233 contributor: fullname: Madill-Thomsen – volume: 2055 start-page: 455 year: 2020 ident: R33-20230918 article-title: Overview of tissue imaging methods publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_21 contributor: fullname: Patel – volume: 2055 start-page: 649 year: 2020 ident: R43-20230918 article-title: Bioinformatics tools and resources for cancer immunotherapy study publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_29 contributor: fullname: Palmisano – volume: 10 start-page: 9 year: 2019 ident: R45-20230918 article-title: Introduction to digital image analysis in whole-slide imaging: a white paper from the digital pathology association publication-title: J Pathol Inform [serial online] doi: 10.4103/jpi.jpi_82_18 contributor: fullname: Aeffner – volume: 4 start-page: 2082 year: 2004 ident: R20-20230918 article-title: Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load publication-title: Am J Transplant doi: 10.1046/j.1600-6143.2004.00603.x contributor: fullname: Drachenberg – year: 2018 ident: R40-20230918 article-title: Feeding hand-crafted features for enhancing the performance of convolutional neural networks publication-title: In: Computer Vision and Pattern Recognition (cs CV) Cornell University: contributor: fullname: Hosseini – volume: 51 start-page: 1679 year: 2019 ident: R32-20230918 article-title: Reliability and accuracy of clinical assessment and digital image analysis for steatosis evaluation in discarded human livers publication-title: Transplant Proc doi: 10.1016/j.transproceed.2019.04.054 contributor: fullname: Abudhaise – volume: 2055 start-page: 521 year: 2020 ident: R36-20230918 article-title: Cyclic multiplexed-immunofluorescence (cmIF), a highly multiplexed method for single-cell analysis publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_24 contributor: fullname: Eng – volume: 21 start-page: 5 year: 2020 ident: R6-20230918 article-title: Impact of the donor-recipient gender matching on the graft survival from live donors publication-title: BMC Nephrol doi: 10.1186/s12882-019-1670-x contributor: fullname: Naderi – volume: 2055 start-page: 585 year: 2020 ident: R37-20230918 article-title: The InSituPlex publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_26 contributor: fullname: Manesse – volume: 2055 start-page: 641 year: 2020 ident: R42-20230918 article-title: Systems Biology for Multiplatform Data Integration: An Overview publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_28 contributor: fullname: Ziv – volume: 2055 start-page: 563 year: 2020 ident: R23-20230918 article-title: High-plex spatially resolved RNA and protein detection using digital spatial profiling: a technology designed for immuno-oncology biomarker discovery and translational research publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_25 contributor: fullname: Beechem – volume: 30 start-page: 1968 year: 2019 ident: R39-20230918 article-title: Deep learning-based histopathologic assessment of kidney tissue publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2019020144 contributor: fullname: Hermsen – volume: 15 start-page: 2780 year: 2015 ident: R10-20230918 article-title: High-resolution HLA typing for sensitized patients: advances in medicine and science require us to challenge existing paradigms publication-title: Am J Transplant doi: 10.1111/ajt.13376 contributor: fullname: Duquesnoy – year: 2020 ident: R27-20230918 article-title: Quantitative proteomics for monitoring renal transplant injury publication-title: Proteomics Clin Appl doi: 10.1002/prca.201900036 contributor: fullname: Song – volume: 557 start-page: 50 year: 2018 ident: R4-20230918 article-title: A randomized trial of normothermic preservation in liver transplantation publication-title: Nature doi: 10.1038/s41586-018-0047-9 contributor: fullname: Nasralla – volume: 19 start-page: 1955 year: 2019 ident: R15-20230918 article-title: Assessing the utilization of high-resolution 2-field HLA typing in solid organ transplantation publication-title: Am J Transplant doi: 10.1111/ajt.15258 contributor: fullname: Huang – volume: 12 start-page: 883 year: 2016 ident: R26-20230918 article-title: Gene-specific correlation of RNA and protein levels in human cells and tissues publication-title: Mol Syst Biol doi: 10.15252/msb.20167144 contributor: fullname: Edfors – volume: 84 start-page: 285 year: 2014 ident: R16-20230918 article-title: Validation of statistical imputation of allele-level multilocus phased genotypes from ambiguous HLA assignments publication-title: Tissue Antigens doi: 10.1111/tan.12390 contributor: fullname: Madbouly – volume: 14 start-page: 403 year: 2009 ident: R12-20230918 article-title: HLAMatchmaker-based definition of structural human leukocyte antigen epitopes detected by alloantibodies publication-title: Curr Opin Organ Transplant doi: 10.1097/MOT.0b013e32832ca2b8 contributor: fullname: Duquesnoy – volume: 2055 start-page: 497 year: 2020 ident: R35-20230918 article-title: Multiplexed immunohistochemical consecutive staining on single slide (MICSSS): multiplexed chromogenic IHC assay for high-dimensional tissue analysis publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-9773-2_23 contributor: fullname: Akturk – volume: 3 start-page: e136 year: 2017 ident: R28-20230918 article-title: Acute rejection phenotypes in the current era of immunosuppression: a single-center analysis publication-title: Transplant Direct doi: 10.1097/TXD.0000000000000650 contributor: fullname: Wehmeier – volume: 103 start-page: 1306 year: 2019 ident: R17-20230918 article-title: Enhancing the value of histopathological assessment of allograft biopsy monitoring publication-title: Transplantation doi: 10.1097/TP.0000000000002656 contributor: fullname: Wood-Trageser – volume: 16 start-page: 67 year: 2019 ident: R41-20230918 article-title: U-Net: deep learning for cell counting, detection, and morphometry publication-title: Nat Methods doi: 10.1038/s41592-018-0261-2 contributor: fullname: Falk |
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| Snippet | Transplant pathology contributes substantially to personalized treatment of organ allograft recipients. Rapidly advancing next-generation human leukocyte... PURPOSE OF REVIEWTransplant pathology contributes substantially to personalized treatment of organ allograft recipients. Rapidly advancing next-generation... |
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| SubjectTerms | Histocompatibility Testing HLA Antigens - immunology Humans Organ Transplantation - methods Precision Medicine - methods Tissue Donors Transplantation Immunology Transplantation, Homologous Transplants - immunology Transplants - pathology |
| Title | Precision transplant pathology |
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