G‐CSF‐mobilized CD34+ peripheral blood stem cells are significantly less apoptotic than unstimulated peripheral blood CD34+ cells: role of G‐CSF as survival factor

The mechanism of release of CD34+ cells into the peripheral blood (PB) after mobilization treatment with chemotherapy and/or growth factors is not clearly understood. Growth factors may induce increased proliferation and self renewal within the stem cell compartment. It is possible that they alter a...

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Bibliographic Details
Published in:	British journal of haematology Vol. 97; no. 1; pp. 146 - 152
Main Authors:	Philpott, N. J., Prue, R. L., Marsh, J. C. W., Gordon‐Smith, E. C., Gibson, F. M.
Format:	Journal Article
Language:	English
Published:	Oxford, U.K. and Cambridge, USA Blackwell Science Ltd 01-04-1997 Blackwell
Subjects:	Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD34 - metabolism apoptosis Apoptosis - physiology Biological and medical sciences Bone Marrow Cells Bone marrow, stem cells transplantation. Graft versus host reaction Female Granulocyte Colony-Stimulating Factor - therapeutic use G‐CSF Hematopoietic Stem Cells - cytology Humans Male Medical sciences Middle Aged stem cells survival factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Human Transfusion Stem cell Cytokine Hematopoietic cell Cell subpopulation Cell surface Survival Blood Antigen Mobilization Granulocyte colony stimulating factor Polypeptide Cell death Graft Apoptosis
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