Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)

• Published in: British journal of nutrition Vol. 78; no. 4; pp. 625 - 637
• Main Authors: Venter, C. S., Nel, C. J., Vorster, H. H., Jerling, J. C., Oosthuizen, W., Veldman, F. J., Kellerman, J. A., Smuts, C. M., Vermaak, W. J. H., Van Der Nest, D. G., Ridder, J. H.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01-10-1997
• Subjects: Analysis of Variance; animal models; Animals; anticholesteremic agents; Baboons; Bezafibrate - therapeutic use; Biological and medical sciences; blood lipids; blood serum; concentrates; Diet; dietary fat; dietary fiber; Dietary Fiber - administration & dosage; dietary supplements; Diseases of the cardiovascular system; enzyme inhibitors; experimental diets; General Nutrition; Glucose - metabolism; high density lipoprotein; Hypolipidemic Agents - therapeutic use; Lipid Metabolism; Lipids - blood; Lipoproteins - blood; Liver - metabolism; Male; Medical sciences; obesity; Obesity - blood; Obesity - drug therapy; Obesity - therapy; Papio; Plasminogen Activator Inhibitor 1 - metabolism; Plasminogen activator inhibitor-1; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Random Allocation; solubility; Soluble-fibre concentrate; triacylglycerols; Triglycerides - blood; Triglycerides - metabolism; Asia; Japan; Soluble-fibre concentrate; Plasminogen activator inhibitor-1; Baboons; Monocotyledones; Cardiovascular disease; t-Plasminogen activator; Folk medicine; Hemostasis; Angiospermae; Primates; Simioidea; Supplementation; Mechanism of action; Serine endopeptidases; Enzyme; Oral administration; Enzyme inhibitor; Coronary heart disease; Cholesterol; Peptidases; Vertebrata; Mammalia; Diet therapy; Araceae; Bezafibrate; Animal; Papio ursinus; Hydrolases; Spermatophyta; Tuber plant; Dietary fiber; Comparative study; Antilipemic agent
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1079/BJN19970179

The effects of a soluble NSP (fibre) concentrate (SFC) on plasma fibrinogen and plasminogen activator inhibitor-1 (PAI-1), serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate (BF), a lipid-lowering drug, in obese baboons (Papio ursinus) The basal diet was a high-fat (37% of total energy), low-NSP (12.4 g/d) Westernized diet, supplemented for 8 weeks with either 20 SFCg/baboon per d or 6.7 mg BF/kg body weight per baboon per d. SFC supplementation significantly lowered PAI-1, total serum cholesterol, HDL-cholesterol and circulating free fatty acid levels. BF significantly lowered total serum cholesterol, but unexpectedly raised serum triacylglycerol levels. Although not statistically significant, the mean liver tricacylglycerol concentration of baboons fed on BF was lower than that of baboons fed on SFC supplements. These results suggest that: (1) the mechanism of action of the two cholesterol-lowering treatments differ, with BF having a liver triacylglycerol-lowering effect and (2) the SFC had additional beneficial effect on fibrinolysis by lowering PAI-1 levels.