The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study

• Published in: The Journal of infectious diseases Vol. 225; no. 4; pp. 617 - 626
• Main Authors: Arriaga, María B, Araújo-Pereira, Mariana, Barreto-Duarte, Beatriz, Nogueira, Betânia, Freire, Maria Vitória C N S, Queiroz, Artur T L, Rodrigues, Moreno M S, Rocha, Michael S, Souza, Alexandra B, Spener-Gomes, Renata, Carvalho, Anna Cristina C, Figueiredo, Marina C, Turner, Megan M, Durovni, Betina, Lapa-e-Silva, José R, Kritski, Afrânio L, Cavalcante, Solange, Rolla, Valeria C, Cordeiro-Santos, Marcelo, Sterling, Timothy R, Andrade, Bruno B
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 15-02-2022
• Subjects: Antitubercular Agents - therapeutic use; Clinical outcomes; Cohort analysis; Cohort Studies; Death; Diabetes; Diabetes mellitus; Diabetes Mellitus - drug therapy; Diabetes Mellitus - epidemiology; Hemoglobin; HIV; Human immunodeficiency virus; Humans; Major and Brief Reports; Prediabetic State - complications; Prediabetic State - drug therapy; Prospective Studies; Regression analysis; Treatment Outcome; Tuberculosis; Tuberculosis - complications; Tuberculosis - drug therapy; Brazil; diabetes; treatment outcome; prediabetes; SINAN; Mycobacterium tuberculosis
• ISSN: 0022-1899; 1537-6613; 1537-6613
• DOI: 10.1093/infdis/jiab427

Abstract
Background
It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).
Methods
Culture-confirmed, drug-susceptible PWTB, enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)–Brazil cohort between 2015 and 2019 (N = 643) were stratified based on glycemic status according to baseline glycated hemoglobin. Unfavorable tuberculosis (TB) outcome was defined as treatment failure or modification, recurrence, or death; favorable outcome was cure or treatment completion. We corroborated the findings using data from PWTB reported to the Brazilian National System of Diseases Notification (SINAN) during 2015–2019 (N = 20 989). Logistic regression models evaluated associations between glycemic status and outcomes.
Results
In both cohorts, in univariate analysis, unfavorable outcomes were more frequently associated with smoking, illicit drug use, and human immunodeficiency virus infection. Diabetes, but not prediabetes, was associated with unfavorable outcomes in the RePORT-Brazil (adjusted relative risk [aRR], 2.45; P < .001) and SINAN (aRR, 1.76; P < .001) cohorts. Furthermore, diabetes was associated with high risk of death (during TB treatment) in both RePORT-Brazil (aRR, 2.16; P = .040) and SINAN (aRR, 1.93; P = .001).
Conclusions
Diabetes was associated with an increased risk of unfavorable outcomes and mortality in Brazilian PWTB. Interventions to improve TB treatment outcomes in persons with diabetes are needed.
In a multicenter prospective cohort study from Brazil, diabetes was associated with an increased risk of unfavorable treatment outcomes, including mortality, in people with pulmonary tuberculosis. These observations were corroborated in the Brazilian National Disease Notification System during the same period.