Difference of bone marrow adipocyte colony-forming capacity between aplastic anemia and iron deficiency anemia

• Published in: Leukemia research Vol. 12; no. 2; p. 179
• Main Authors: Hirata, J, Umemura, T, Kaneko, S, Nishimura, J, Motomura, S, Ibayashi, H
• Format: Journal Article
• Language: English
• Published: England 1988
• Subjects: Adipose Tissue - pathology; Anemia, Aplastic - pathology; Anemia, Hypochromic - pathology; Anemia, Refractory - pathology; Anemia, Refractory, with Excess of Blasts - pathology; Bone Marrow - pathology; Colony-Forming Units Assay; Humans
• DOI: 10.1016/0145-2126(88)90079-3
• ISSN: 0145-2126

The bone marrow adipocyte colony-forming capacity (Adipo-CFC) in patients with aplastic anemia (AA), myelodysplastic syndrome (MDS) and iron deficiency anemia (IDA) was studied. Before treatment, Adipo-CFC in IDA was higher than that in AA and MDS. After treatment, Adipo-CFC decreased in IDA, but it increased in AA and MDS only at the responsive stage. In this context, it is suggested that increase of Adipo-CFC occurs during not only regenerating hemopoiesis but also accelerated erythropoiesis such as severe IDA. Colony-stimulating activity (CSA) production by marrow stromal cells (MSC) in AA was lower than that in normal subjects. Low Adipo-CFC and defective CSA production by MSC may explain in part the pathogenesis of microenvironmental defect in AA.