Local adverse effects associated with the use of inhaled corticosteroids in patients with moderate or severe asthma
To describe and characterize local adverse effects (in the oral cavity, pharynx, and larynx) associated with the use of inhaled corticosteroids (ICSs) in patients with moderate or severe asthma. This was a cross-sectional study involving a convenience sample of 200 asthma patients followed in the De...
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| Published in: | Jornal brasileiro de pneumologia Vol. 39; no. 4; pp. 409 - 417 |
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| Main Authors: | , , , , , |
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Brazil
Sociedade Brasileira de Pneumologia e Tisiologia
01-06-2013
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| Abstract | To describe and characterize local adverse effects (in the oral cavity, pharynx, and larynx) associated with the use of inhaled corticosteroids (ICSs) in patients with moderate or severe asthma.
This was a cross-sectional study involving a convenience sample of 200 asthma patients followed in the Department of Pharmaceutical Care of the Bahia State Asthma and Allergic Rhinitis Control Program Referral Center, located in the city of Salvador, Brazil. The patients were ≥ 18 years of age and had been using ICSs regularly for at least 6 months. Local adverse effects (irritation, pain, dry throat, throat clearing, hoarseness, reduced vocal intensity, loss of voice, sensation of thirst, cough during ICS use, altered sense of taste, and presence of oral candidiasis) were assessed using a 30-day recall questionnaire.
Of the 200 patients studied, 159 (79.5%) were women. The mean age was 50.7 ± 14.4 years. In this sample, 55 patients (27.5%) were using high doses of ICS, with a median treatment duration of 38 months. Regarding the symptoms, 163 patients (81.5%) reported at least one adverse effect, and 131 (65.5%) had a daily perception of at least one symptom. Vocal and pharyngeal symptoms were identified in 57 (28.5%) and 154 (77.0%) of the patients, respectively. The most commonly reported adverse effects were dry throat, throat clearing, sensation of thirst, and hoarseness.
Self-reported adverse effects related to ICS use were common among the asthma patients evaluated here. |
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| AbstractList | To describe and characterize local adverse effects (in the oral cavity, pharynx, and larynx) associated with the use of inhaled corticosteroids (ICSs) in patients with moderate or severe asthma.
This was a cross-sectional study involving a convenience sample of 200 asthma patients followed in the Department of Pharmaceutical Care of the Bahia State Asthma and Allergic Rhinitis Control Program Referral Center, located in the city of Salvador, Brazil. The patients were ≥ 18 years of age and had been using ICSs regularly for at least 6 months. Local adverse effects (irritation, pain, dry throat, throat clearing, hoarseness, reduced vocal intensity, loss of voice, sensation of thirst, cough during ICS use, altered sense of taste, and presence of oral candidiasis) were assessed using a 30-day recall questionnaire.
Of the 200 patients studied, 159 (79.5%) were women. The mean age was 50.7 ± 14.4 years. In this sample, 55 patients (27.5%) were using high doses of ICS, with a median treatment duration of 38 months. Regarding the symptoms, 163 patients (81.5%) reported at least one adverse effect, and 131 (65.5%) had a daily perception of at least one symptom. Vocal and pharyngeal symptoms were identified in 57 (28.5%) and 154 (77.0%) of the patients, respectively. The most commonly reported adverse effects were dry throat, throat clearing, sensation of thirst, and hoarseness.
Self-reported adverse effects related to ICS use were common among the asthma patients evaluated here. OBJECTIVE: To describe and characterize local adverse effects (in the oral cavity, pharynx, and larynx) associated with the use of inhaled corticosteroids (ICSs) in patients with moderate or severe asthma. METHODS: This was a cross-sectional study involving a convenience sample of 200 asthma patients followed in the Department of Pharmaceutical Care of the Bahia State Asthma and Allergic Rhinitis Control Program Referral Center, located in the city of Salvador, Brazil. The patients were ≥ 18 years of age and had been using ICSs regularly for at least 6 months. Local adverse effects (irritation, pain, dry throat, throat clearing, hoarseness, reduced vocal intensity, loss of voice, sensation of thirst, cough during ICS use, altered sense of taste, and presence of oral candidiasis) were assessed using a 30-day recall questionnaire. RESULTS: Of the 200 patients studied, 159 (79.5%) were women. The mean age was 50.7 ± 14.4 years. In this sample, 55 patients (27.5%) were using high doses of ICS, with a median treatment duration of 38 months. Regarding the symptoms, 163 patients (81.5%) reported at least one adverse effect, and 131 (65.5%) had a daily perception of at least one symptom. Vocal and pharyngeal symptoms were identified in 57 (28.5%) and 154 (77.0%) of the patients, respectively. The most commonly reported adverse effects were dry throat, throat clearing, sensation of thirst, and hoarseness. CONCLUSIONS: Self-reported adverse effects related to ICS use were common among the asthma patients evaluated here. OBJECTIVE: To describe and characterize local adverse effects (in the oral cavity, pharynx, and larynx) associated with the use of inhaled corticosteroids (ICSs) in patients with moderate or severe asthma. METHODS: This was a cross-sectional study involving a convenience sample of 200 asthma patients followed in the Department of Pharmaceutical Care of the Bahia State Asthma and Allergic Rhinitis Control Program Referral Center, located in the city of Salvador, Brazil. The patients were ≥ 18 years of age and had been using ICSs regularly for at least 6 months. Local adverse effects (irritation, pain, dry throat, throat clearing, hoarseness, reduced vocal intensity, loss of voice, sensation of thirst, cough during ICS use, altered sense of taste, and presence of oral candidiasis) were assessed using a 30-day recall questionnaire. RESULTS: Of the 200 patients studied, 159 (79.5%) were women. The mean age was 50.7 ± 14.4 years. In this sample, 55 patients (27.5%) were using high doses of ICS, with a median treatment duration of 38 months. Regarding the symptoms, 163 patients (81.5%) reported at least one adverse effect, and 131 (65.5%) had a daily perception of at least one symptom. Vocal and pharyngeal symptoms were identified in 57 (28.5%) and 154 (77.0%) of the patients, respectively. The most commonly reported adverse effects were dry throat, throat clearing, sensation of thirst, and hoarseness. CONCLUSIONS: Self-reported adverse effects related to ICS use were common among the asthma patients evaluated here. OBJETIVO: Descrever e caracterizar os eventos adversos locais na orofaringe e laringe associados ao uso de corticosteroide inalatório (CI) em pacientes com asma moderada ou grave. MÉTODOS: Estudo de corte transversal, com amostra de conveniência composta por 200 pacientes acompanhados no Serviço de Assistência Farmacêutica da Central de Referência do Programa para Controle da Asma na Bahia, em Salvador (BA). Os pacientes tinham ≥ 18 anos e estavam em uso regular de CI por período ≥ 6 meses. Os eventos adversos locais (irritação, dor, garganta seca, pigarro, rouquidão, redução da potência da voz, perda de voz; sensação de sede, tosse durante inalação, alteração do paladar e presença de monilíase oral) foram avaliados por meio de um questionário com período recordatório de 30 dias. RESULTADOS: Dos 200 pacientes estudados, 159 (79,5%) eram mulheres. A média de idade foi de 50,7 ± 14,4 anos. Nesta amostra, 55 pacientes (27,5%) utilizavam altas doses de CI, com mediana de duração de tratamento de 38 meses. Em relação aos sintomas, 163 pacientes (81,5%) reportaram ao menos um evento adverso, e 131 (65,5%) tinham a percepção diária de pelo menos um sintoma. Os sintomas de voz e de faringe foram identificados em 57 (28,5%) e 154 (77,0%) pacientes, respectivamente. Os eventos adversos mais frequentemente relatados foram garganta seca, pigarros, sensação de sede e rouquidão. CONCLUSÕES: Eventos adversos relacionados ao uso de CI foram queixas frequentemente referidas e percebidas por esta amostra de asmáticos. |
| Author | Costa, Lindemberg Assunção Marques, Thamy Santana Yamamura, Laira Lorena Lima Pinto, Charleston Ribeiro Souza-Machado, Adelmir Almeida, Natalie Rios |
| AuthorAffiliation | Universidade Estadual do Sudoeste da Bahia Secretaria de Estado da Saúde da Bahia Hospital Geral Roberto Santos Universidade Federal da Bahia Escola Bahiana de Medicina e Saúde Pública |
| AuthorAffiliation_xml | – name: Universidade Estadual do Sudoeste da Bahia – name: Universidade Federal da Bahia – name: Secretaria de Estado da Saúde da Bahia – name: Hospital Geral Roberto Santos – name: Escola Bahiana de Medicina e Saúde Pública |
| Author_xml | – sequence: 1 givenname: Charleston Ribeiro surname: Pinto fullname: Pinto, Charleston Ribeiro organization: Department of Chemistry and Exact Sciences, Southwestern Bahia State University, Jequié, Brazil – sequence: 2 givenname: Natalie Rios surname: Almeida fullname: Almeida, Natalie Rios – sequence: 3 givenname: Thamy Santana surname: Marques fullname: Marques, Thamy Santana – sequence: 4 givenname: Laira Lorena Lima surname: Yamamura fullname: Yamamura, Laira Lorena Lima – sequence: 5 givenname: Lindemberg Assunção surname: Costa fullname: Costa, Lindemberg Assunção – sequence: 6 givenname: Adelmir surname: Souza-Machado fullname: Souza-Machado, Adelmir |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24068261$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1089/jamp.2009.0762 10.1017/S0022215107001272 10.1016/S0002-9343(99)80404-5 10.1034/j.1398-9995.2001.00100.x 10.1136/thx.38.11.813 10.1111/j.1365-2710.2011.01258.x 10.1155/2008/593723 10.1378/chest.126.1.213 10.1111/j.1398-9995.2006.01090.x 10.1016/j.rmed.2008.10.028 10.1183/09031936.95.08040590 10.1007/s00228-007-0339-8 10.1016/j.jvoice.2003.05.003 10.1378/chest.113.3.587 10.1186/1465-9921-7-131 10.1016/j.rmed.2005.11.029 10.1016/j.jvoice.2005.09.003 10.1001/archinte.1994.00420230150018 10.1016/j.socscimed.2004.01.019 |
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| Keywords | Administracao por inalacao Glucocorticoids Assistencia farmaceutica Administration, inhalation Asma Pharmaceutical services Glucocorticoides Asthma |
| Language | English Portuguese |
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| Snippet | To describe and characterize local adverse effects (in the oral cavity, pharynx, and larynx) associated with the use of inhaled corticosteroids (ICSs) in... OBJECTIVE: To describe and characterize local adverse effects (in the oral cavity, pharynx, and larynx) associated with the use of inhaled corticosteroids... |
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| SubjectTerms | Administracao por inalacao Administration, Inhalation Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - adverse effects Asma Assistencia farmaceutica Asthma - drug therapy Beclomethasone - administration & dosage Beclomethasone - adverse effects Budesonide - administration & dosage Budesonide - adverse effects Cross-Sectional Studies Female Glucocorticoides Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Hoarseness - chemically induced Humans Male Middle Aged Original Oropharynx - drug effects RESPIRATORY SYSTEM Severity of Illness Index Thirst |
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| Title | Local adverse effects associated with the use of inhaled corticosteroids in patients with moderate or severe asthma |
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