Anti-tumor promoting activity of Dryopteris phlorophenone derivatives

• Published in: Cancer letters Vol. 105; no. 2; pp. 161 - 165
• Main Authors: Kapadia, Govind J., Tokuda, Harukuni, Konoshima, Takao, Takasaki, Midori, Takayasu, Junko, Nishino, Hoyoku
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Shannon Elsevier Ireland Ltd 02-08-1996; Elsevier
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Butyrophenones - chemistry; Butyrophenones - pharmacology; Butyrophenones - therapeutic use; Cancer inhibitory effect; Dryopteris; Female; General pharmacology; Herpesvirus 4, Human - drug effects; Medical sciences; Mice; Mice, Inbred ICR; Papilloma - drug therapy; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phloroglucinol - analogs & derivatives; Phloroglucinol - pharmacology; Phloroglucinol - therapeutic use; Phlorophenones; Plant Extracts - chemistry; Plant Extracts - pharmacology; Skin Neoplasms - drug therapy; Virus Activation - drug effects; Cancer inhibitory effect; Dryopteris; Phlorophenones; Antineoplastic agent; Chemotherapy; Treatment; Structure activity relation; Pharmacognosy; Analog; Plant origin; Phloroglucinol; Pteridophyta; In vitro; Biological activity; Filicineae
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/0304-3835(96)04275-9

As a part of screening studies for cancer chemopreventive agents (anti-tumor promoters) 33
Dryopteris phlorophenone derivatives have been evaluated. The compounds tested comprised of monomeric acylphloroglucinols (e.g. desaspidinol, aspidinol) as well as dimeric (e.g. aspidin, desaspidin), trimeric (e.g. filixic acids), and tetrameric (e.g. dryocrassin) phlorophenone, wherein hexacyclic rings are bound together by a methylene bridge. These compounds were examined for their in vitro anti-tumor promoting effect on Epstein-Barr virus antigen activation induced by the tumor promoter 12-
O-tetradecanoylphorbol-13-acetate (TPA). The two dimeric compounds aspidin and desaspidin, which were found to be the most active among the tested phlorophenones, were also examined in vivo on two stage mouse skin carcinogenesis, and found to show significant inhibitory effect on 7,12-dimethylbenz [
a]anthracene (DMBA)-TPA tumor promotion.