Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review
Mesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes of administration of MSCs have been described both in pre-clinical and clinical reports. Knowledge about the fate of the administered cells is critical for developing MSC-based therapies. The aim of this rev...
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| Published in: | Journal of clinical medicine Vol. 10; no. 13; p. 2925 |
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| Main Authors: | , , , , , , |
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| Abstract | Mesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes of administration of MSCs have been described both in pre-clinical and clinical reports. Knowledge about the fate of the administered cells is critical for developing MSC-based therapies. The aim of this review is to describe how MSCs are distributed after injection, using different administration routes in animal models and humans. A literature search was performed in order to consider how MSCs distribute after intravenous, intraarterial, intramuscular, intraarticular and intralesional injection into both animal models and humans. Studies addressing the biodistribution of MSCs in “in vivo” animal models and humans were included. After the search, 109 articles were included in the review. Intravenous administration of MSCs is widely used; it leads to an initial accumulation of cells in the lungs with later redistribution to the liver, spleen and kidneys. Intraarterial infusion bypasses the lungs, so MSCs distribute widely throughout the rest of the body. Intramuscular, intraarticular and intradermal administration lack systemic biodistribution. Injection into various specific organs is also described. Biodistribution of MSCs in animal models and humans appears to be similar and depends on the route of administration. More studies with standardized protocols of MSC administration could be useful in order to make results homogeneous and more comparable. |
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| AbstractList | Mesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes of administration of MSCs have been described both in pre-clinical and clinical reports. Knowledge about the fate of the administered cells is critical for developing MSC-based therapies. The aim of this review is to describe how MSCs are distributed after injection, using different administration routes in animal models and humans. A literature search was performed in order to consider how MSCs distribute after intravenous, intraarterial, intramuscular, intraarticular and intralesional injection into both animal models and humans. Studies addressing the biodistribution of MSCs in “in vivo” animal models and humans were included. After the search, 109 articles were included in the review. Intravenous administration of MSCs is widely used; it leads to an initial accumulation of cells in the lungs with later redistribution to the liver, spleen and kidneys. Intraarterial infusion bypasses the lungs, so MSCs distribute widely throughout the rest of the body. Intramuscular, intraarticular and intradermal administration lack systemic biodistribution. Injection into various specific organs is also described. Biodistribution of MSCs in animal models and humans appears to be similar and depends on the route of administration. More studies with standardized protocols of MSC administration could be useful in order to make results homogeneous and more comparable. |
| Author | Sanabria de la Torre, Raquel Quiñones-Vico, Maria I. Sanchez-Diaz, Manuel Montero-Vílchez, Trinidad Molina-Leyva, Alejandro Sierra-Sánchez, Alvaro Arias-Santiago, Salvador |
| AuthorAffiliation | 1 Dermatology Department, Hospital Universitario Virgen de las Nieves, IBS Granada, 18014 Granada, Spain; manolo.94.sanchez@gmail.com (M.S.-D.); tmonterov@gmail.com (T.M.-V.); alejandromolinaleyva@gmail.com (A.M.-L.); salvadorarias@ugr.es (S.A.-S.) 2 Cellular Production Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18014 Granada, Spain; raquelsanabriadlt@gmail.com (R.S.d.l.T.); alvarosisan@gmail.com (A.S.-S.) 3 School of Medicine, University of Granada, 18014 Granada, Spain |
| AuthorAffiliation_xml | – name: 3 School of Medicine, University of Granada, 18014 Granada, Spain – name: 1 Dermatology Department, Hospital Universitario Virgen de las Nieves, IBS Granada, 18014 Granada, Spain; manolo.94.sanchez@gmail.com (M.S.-D.); tmonterov@gmail.com (T.M.-V.); alejandromolinaleyva@gmail.com (A.M.-L.); salvadorarias@ugr.es (S.A.-S.) – name: 2 Cellular Production Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18014 Granada, Spain; raquelsanabriadlt@gmail.com (R.S.d.l.T.); alvarosisan@gmail.com (A.S.-S.) |
| Author_xml | – sequence: 1 givenname: Manuel orcidid: 0000-0002-3626-1558 surname: Sanchez-Diaz fullname: Sanchez-Diaz, Manuel – sequence: 2 givenname: Maria I. surname: Quiñones-Vico fullname: Quiñones-Vico, Maria I. – sequence: 3 givenname: Raquel surname: Sanabria de la Torre fullname: Sanabria de la Torre, Raquel – sequence: 4 givenname: Trinidad orcidid: 0000-0003-4035-7955 surname: Montero-Vílchez fullname: Montero-Vílchez, Trinidad – sequence: 5 givenname: Alvaro orcidid: 0000-0003-4511-408X surname: Sierra-Sánchez fullname: Sierra-Sánchez, Alvaro – sequence: 6 givenname: Alejandro orcidid: 0000-0001-6882-2113 surname: Molina-Leyva fullname: Molina-Leyva, Alejandro – sequence: 7 givenname: Salvador surname: Arias-Santiago fullname: Arias-Santiago, Salvador |
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| Cites_doi | 10.1002/stem.2779 10.1016/j.nucmedbio.2011.03.008 10.1007/s10616-017-0097-0 10.3390/ijms19092783 10.1177/0963689718788067 10.1177/0963689719885078 10.1186/s13287-015-0271-2 10.1097/TP.0000000000001773 10.1002/advs.201901018 10.1200/JCO.2000.18.2.307 10.3727/096368914X685276 10.2147/IJN.S146742 10.3791/55367 10.2147/IJN.S97073 10.1186/s13287-018-1123-7 10.1089/scd.2019.0074 10.1634/stemcells.2007-0439 10.1007/s11307-018-1204-0 10.1016/j.bpobgyn.2015.08.009 10.18632/oncotarget.19775 10.3791/61117-v 10.1097/RLU.0000000000000850 10.1002/sctm.18-0024 10.1089/scd.2019.0176 10.1016/j.jcyt.2014.12.004 10.1007/s10517-020-04750-8 10.1186/s13287-015-0036-y 10.1186/s13287-018-1083-y 10.1186/s13287-015-0236-5 10.1177/0963689717739718 10.3389/fimmu.2017.01465 10.3727/096368914X679336 10.2147/IJN.S167142 10.1111/vsu.12485 10.7150/thno.27559 10.1007/s00192-015-2831-5 10.1089/scd.2016.0338 10.1186/s13287-020-01770-z 10.1186/s13287-015-0017-1 10.1016/j.stem.2009.05.003 10.1002/ijc.31113 10.46582/jsrm.1102007 10.3389/fimmu.2017.00638 10.1177/0022034512460404 10.4252/wjsc.v11.i2.100 10.1080/14653240600855905 10.1016/0014-4827(91)90401-F 10.1016/j.yexmp.2015.01.016 10.1186/s13550-015-0098-y 10.5966/sctm.2015-0023 10.1634/stemcells.2007-0197 10.1136/bmjresp-2018-000308 10.1182/blood-2002-06-1830 10.1186/s13287-018-0775-7 10.1016/j.jdermsci.2014.10.004 10.1016/j.jcyt.2018.03.032 10.1111/jcmm.12571 10.12659/MSM.900512 10.1007/s11307-016-0962-9 10.1007/s10571-014-0135-9 10.1007/s13770-019-00202-1 10.1080/00365521.2017.1281434 10.1111/jdv.13934 10.1016/j.jcyt.2017.04.002 10.1039/C9NR01395D 10.1016/j.nucmedbio.2016.12.003 10.3109/02699052.2015.1053525 10.1161/CIRCULATIONAHA.105.537480 10.1089/scd.2019.0105 10.3791/56273-v 10.1111/liv.12962 10.1016/j.jcyt.2016.09.010 10.1186/s13287-018-1076-x 10.1186/s13287-018-0900-7 10.1038/s41598-018-22750-7 10.1016/j.biomaterials.2016.08.027 10.5966/sctm.2015-0379 10.1002/sctm.19-0091 10.3791/740 10.1002/stem.1848 10.3390/ijms21041272 10.1182/blood.V98.8.2396 10.1152/ajprenal.00098.2008 10.1016/j.nucmedbio.2015.12.003 10.1038/srep42793 10.1016/j.jcyt.2015.10.011 10.1089/scd.2017.0248 10.1002/sctm.18-0208 10.12659/MSM.897044 10.21037/sci.2019.08.06 10.1186/s13287-017-0533-2 10.3109/0886022X.2015.1073542 10.1007/s12015-016-9694-0 10.1016/j.yrtph.2016.09.029 10.3727/096368916X692104 10.1007/s11307-014-0792-6 10.3727/096368915X688191 10.1016/j.scr.2015.06.010 10.1089/scd.2016.0020 10.1155/2016/8616143 10.1371/journal.pone.0114962 10.1016/j.jcyt.2018.12.005 10.1016/j.jcyt.2014.12.006 10.3727/096368915X689604 10.3727/096368915X690189 10.1016/j.jcyt.2016.12.003 10.3727/096368914X685654 10.1159/000443636 10.1002/rcm.8505 10.1007/s00018-017-2473-5 10.1007/s10517-016-3565-1 10.1016/j.biopha.2017.10.127 10.1161/STROKEAHA.107.502047 10.1186/s13287-018-0849-6 10.1159/000367826 10.1097/SCS.0000000000003563 10.1002/cmmi.1650 10.1091/mbc.e02-02-0105 10.1186/s13287-016-0420-2 10.1186/s12929-016-0289-5 10.1007/s11307-019-01458-8 10.1111/cts.12284 10.3892/mmr.2014.2805 10.1016/j.neurobiolaging.2016.08.002 10.1371/journal.pone.0122377 10.1007/s10439-020-02487-z 10.1016/j.jaad.2009.09.022 10.1089/scd.2014.0240 10.3390/ijms19092564 10.1111/jcmm.13331 10.1155/2016/3970942 10.1186/s13287-017-0714-z 10.1038/s41598-020-70291-9 10.1002/jbm.a.35891 |
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| Copyright | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 by the authors. 2021 |
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| References | Lebouvier (ref_78) 2015; 6 ref_137 Khan (ref_71) 2018; 9 Patrick (ref_127) 2020; 11 Tang (ref_129) 2016; 36 Campagnoli (ref_1) 2001; 98 Burk (ref_72) 2016; 25 Li (ref_67) 2016; 7 ref_19 Qin (ref_41) 2017; 17 Mamani (ref_92) 2019; 11 Ginner (ref_75) 2019; 9 Kim (ref_38) 2015; 6 Chamberlain (ref_11) 2007; 25 Hassan (ref_6) 2019; 6 Zhang (ref_138) 2017; 8 Kim (ref_36) 2015; 11 Duan (ref_88) 2017; 12 Wang (ref_123) 2012; 91 ref_120 Lebouvier (ref_77) 2015; 24 Luk (ref_32) 2018; 36 Scarfe (ref_48) 2018; 9 Kim (ref_30) 2016; 106 Kim (ref_15) 2017; 31 Dou (ref_81) 2019; 28 Ohta (ref_37) 2017; 19 Bansal (ref_108) 2015; 5 Xie (ref_87) 2016; 22 Li (ref_27) 2018; 9 Ryu (ref_80) 2018; 8 Packthongsuk (ref_105) 2018; 9 Khabbal (ref_51) 2015; 24 Hsu (ref_102) 2017; 26 Schmuck (ref_43) 2016; 5 Pratheesh (ref_113) 2017; 69 Troyer (ref_5) 2008; 26 Yun (ref_31) 2016; 81 Najar (ref_125) 2016; 18 ref_74 Geng (ref_91) 2014; 11 Wuttisarnwattana (ref_128) 2020; 48 Krueger (ref_126) 2018; 7 Estrada (ref_63) 2018; 27 Loukogeorgakis (ref_9) 2016; 31 Markides (ref_70) 2019; 10 Fukuda (ref_56) 2015; 35 Wang (ref_134) 2015; 11 Thibaud (ref_60) 2020; 10 Teo (ref_139) 2015; 33 Nemeth (ref_4) 2015; 77 Jiang (ref_109) 2018; 22 Cao (ref_50) 2018; 142 Gholamrezanezhad (ref_115) 2011; 38 Yang (ref_47) 2008; 295 Dong (ref_95) 2017; 28 Leibacher (ref_132) 2016; 7 Takalo (ref_22) 2015; 17 ref_84 Lobo (ref_10) 2016; 201 Shende (ref_18) 2018; 97 Liew (ref_23) 2014; 32 Davies (ref_65) 2019; 8 Mezzanotte (ref_94) 2017; 26 Sokal (ref_117) 2017; 101 Creane (ref_61) 2017; 19 Ryska (ref_106) 2017; 52 Henriksson (ref_118) 2019; 28 Ohki (ref_93) 2020; 10 Vaquero (ref_20) 2018; 20 Cai (ref_64) 2017; 105 Lezaic (ref_119) 2016; 43 Munk (ref_57) 2019; 28 ref_54 Montellano (ref_21) 2017; 46 Tappenbeck (ref_112) 2019; 21 Mello (ref_39) 2020; 29 Lu (ref_40) 2016; 25 Kallmeyer (ref_114) 2020; 9 Fabian (ref_46) 2017; 8 Espinosa (ref_59) 2016; 45 Ehrhart (ref_35) 2016; 25 Wang (ref_86) 2018; 13 Arnberg (ref_58) 2016; 25 Teeman (ref_121) 2019; 11 Lee (ref_25) 2009; 5 Devine (ref_26) 2003; 101 Taylor (ref_55) 2020; 22 Kraitchman (ref_24) 2005; 112 Zuk (ref_3) 2002; 13 Sellheyer (ref_8) 2010; 63 ref_68 Khan (ref_2) 2012; 7 ref_66 Zhu (ref_82) 2015; 19 Zhou (ref_131) 2015; 10 Jin (ref_135) 2016; 2016 Cipriani (ref_13) 2015; 17 Leibacher (ref_28) 2017; 19 Quesada (ref_85) 2019; 16 Dominici (ref_12) 2006; 8 Silachev (ref_49) 2016; 162 Barberini (ref_83) 2018; 9 Xie (ref_99) 2018; 21 ref_116 Li (ref_45) 2014; 17 Lee (ref_89) 2017; 13 Park (ref_34) 2018; 27 Cerri (ref_52) 2015; 4 ref_111 Walczak (ref_133) 2008; 39 ref_110 Nakahara (ref_7) 1991; 195 Ezquer (ref_16) 2018; 8 Cao (ref_130) 2016; 2016 Park (ref_96) 2016; 47 Nakada (ref_62) 2019; 33 Wang (ref_14) 2016; 22 Ikuta (ref_76) 2015; 8 ref_104 ref_103 Li (ref_124) 2017; 74 Violatto (ref_97) 2015; 15 Shim (ref_73) 2015; 24 Liu (ref_29) 2018; 41 Sadeghi (ref_79) 2016; 27 ref_107 Wang (ref_17) 2016; 23 Zhang (ref_33) 2015; 37 Sukhinich (ref_53) 2020; 168 Li (ref_98) 2015; 98 ref_44 Sood (ref_122) 2015; 40 Melen (ref_90) 2015; 29 Abramowski (ref_42) 2016; 25 Liu (ref_100) 2016; 19 Li (ref_136) 2017; 8 Delling (ref_69) 2015; 24 Yaochite (ref_101) 2015; 6 |
| References_xml | – volume: 36 start-page: 602 year: 2018 ident: ref_32 article-title: Faculty Opinions recommendation of Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells publication-title: Stem Cells doi: 10.1002/stem.2779 contributor: fullname: Luk – volume: 38 start-page: 961 year: 2011 ident: ref_115 article-title: In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis publication-title: Nucl. Med. Biol. doi: 10.1016/j.nucmedbio.2011.03.008 contributor: fullname: Gholamrezanezhad – volume: 69 start-page: 841 year: 2017 ident: ref_113 article-title: Evaluation of persistence and distribution of intra-dermally administered PKH26 labelled goat bone marrow derived mesenchymal stem cells in cutaneous wound healing model publication-title: Cytotechnology doi: 10.1007/s10616-017-0097-0 contributor: fullname: Pratheesh – ident: ref_19 doi: 10.3390/ijms19092783 – volume: 27 start-page: 1203 year: 2018 ident: ref_34 article-title: In vivo tracking of intravenously injected mesenchymal stem cells in an Alzheimer’s animal model publication-title: Cell Transplant. doi: 10.1177/0963689718788067 contributor: fullname: Park – volume: 28 start-page: 1542 year: 2019 ident: ref_81 article-title: Non-Invasive Cell Tracking with Brighter and Red-Transferred Luciferase for Potential Application in Stem Cell Therapy publication-title: Cell Transplant. doi: 10.1177/0963689719885078 contributor: fullname: Dou – volume: 7 start-page: 1 year: 2016 ident: ref_132 article-title: Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-015-0271-2 contributor: fullname: Leibacher – volume: 101 start-page: 1845 year: 2017 ident: ref_117 article-title: Biodistribution of Liver-Derived Mesenchymal Stem Cells After Peripheral Injection in a Hemophilia A Patient publication-title: Transplantation doi: 10.1097/TP.0000000000001773 contributor: fullname: Sokal – ident: ref_74 doi: 10.1002/advs.201901018 – ident: ref_116 doi: 10.1200/JCO.2000.18.2.307 – volume: 24 start-page: 1945 year: 2015 ident: ref_77 article-title: Bone-Forming Capacity and Biodistribution of Bone Marrow-Derived Stromal Cells Directly Loaded into Scaffolds: A Novel and Easy Approach for Clinical Application of Bone Regeneration publication-title: Cell Transplant. doi: 10.3727/096368914X685276 contributor: fullname: Lebouvier – volume: 12 start-page: 6705 year: 2017 ident: ref_88 article-title: The long-term fate of mesenchymal stem cells labeled with magnetic resonance imaging-visible polymersomes in cerebral ischemia publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S146742 contributor: fullname: Duan – ident: ref_54 doi: 10.3791/55367 – volume: 11 start-page: 13 year: 2015 ident: ref_36 article-title: In vivo near-infrared imaging for the tracking of systemically delivered mesenchymal stem cells: Tropism for brain tumors and biodistribution publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S97073 contributor: fullname: Kim – volume: 10 start-page: 25 year: 2019 ident: ref_70 article-title: Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-018-1123-7 contributor: fullname: Markides – volume: 28 start-page: 1203 year: 2019 ident: ref_118 article-title: The Traceability of Mesenchymal Stromal Cells After Injection Into Degenerated Discs in Patients with Low Back Pain publication-title: Stem Cells Dev. doi: 10.1089/scd.2019.0074 contributor: fullname: Henriksson – volume: 26 start-page: 591 year: 2008 ident: ref_5 article-title: Wharton’s jelly-derived cells are a primitive stromal cell population publication-title: Stem Cells doi: 10.1634/stemcells.2007-0439 contributor: fullname: Troyer – volume: 21 start-page: 44 year: 2018 ident: ref_99 article-title: Bioluminescence Imaging of Transplanted Mesenchymal Stem Cells by Overexpression of Hepatocyte Nuclear Factor4α: Tracking Biodistribution and Survival publication-title: Mol. Imaging Biol. doi: 10.1007/s11307-018-1204-0 contributor: fullname: Xie – volume: 31 start-page: 45 year: 2016 ident: ref_9 article-title: Stem cells from amniotic fluid—Potential for regenerative medicine publication-title: Best Pract. Res. Clin. Obstet. Gynaecol. doi: 10.1016/j.bpobgyn.2015.08.009 contributor: fullname: Loukogeorgakis – volume: 8 start-page: 58985 year: 2017 ident: ref_138 article-title: Magnetic resonance imaging tracking and assessing repair function of the bone marrow mesenchymal stem cells transplantation in a rat model of spinal cord injury publication-title: Oncotarget doi: 10.18632/oncotarget.19775 contributor: fullname: Zhang – ident: ref_110 doi: 10.3791/61117-v – volume: 40 start-page: 697 year: 2015 ident: ref_122 article-title: Biodistribution of 18F-FDG-Labeled Autologous Bone Marrow-Derived Stem Cells in Patients With Type 2 Diabetes Mellitus: Exploring Targeted and Intravenous Routes of Delivery publication-title: Clin. Nucl. Med. doi: 10.1097/RLU.0000000000000850 contributor: fullname: Sood – volume: 7 start-page: 651 year: 2018 ident: ref_126 article-title: Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise publication-title: Stem Cells Transl. Med. doi: 10.1002/sctm.18-0024 contributor: fullname: Krueger – volume: 29 start-page: 586 year: 2020 ident: ref_39 article-title: Intravenous Human Umbilical Cord-Derived Mesenchymal Stromal Cell Administration in Models of Moderate and Severe Intracerebral Hemorrhage publication-title: Stem Cells Dev. doi: 10.1089/scd.2019.0176 contributor: fullname: Mello – volume: 17 start-page: 392 year: 2015 ident: ref_22 article-title: Safety and biodistribution study of bone marrow–derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model publication-title: Cytotherapy doi: 10.1016/j.jcyt.2014.12.004 contributor: fullname: Takalo – volume: 168 start-page: 542 year: 2020 ident: ref_53 article-title: Distribution and Migration of Human Placental Mesenchymal Stromal Cells in the Brain of Healthy Rats after Stereotaxic or Intra-Arterial Transplantation publication-title: Bull. Exp. Biol. Med. doi: 10.1007/s10517-020-04750-8 contributor: fullname: Sukhinich – volume: 6 start-page: 1 year: 2015 ident: ref_78 article-title: Development of a simple procedure for the treatment of femoral head osteonecrosis with intra-osseous injection of bone marrow mesenchymal stromal cells: Study of their biodistribution in the early time points after injection publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-015-0036-y contributor: fullname: Lebouvier – volume: 9 start-page: 335 year: 2018 ident: ref_27 article-title: Targeted migration of bone marrow mesenchymal stem cells inhibits silica-induced pulmonary fibrosis in rats publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-018-1083-y contributor: fullname: Li – volume: 6 start-page: 229 year: 2015 ident: ref_38 article-title: Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-015-0236-5 contributor: fullname: Kim – volume: 26 start-page: 1878 year: 2017 ident: ref_94 article-title: Optimized longitudinal monitoring of stem cell grafts in mouse brain using a novel bioluminescent/near infrared fluorescent fusion reporter publication-title: Cell Transplant. doi: 10.1177/0963689717739718 contributor: fullname: Mezzanotte – ident: ref_104 doi: 10.3389/fimmu.2017.01465 – volume: 24 start-page: 819 year: 2015 ident: ref_51 article-title: Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells from the Brain after Intra-arterial Infusion in Rats publication-title: Cell Transplant. doi: 10.3727/096368914X679336 contributor: fullname: Khabbal – volume: 13 start-page: 5231 year: 2018 ident: ref_86 article-title: Mesenchymal stem cells loaded with paclitaxel–poly(lactic-co-glycolic acid) nanoparticles for glioma-targeting therapy publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S167142 contributor: fullname: Wang – volume: 45 start-page: 619 year: 2016 ident: ref_59 article-title: Scintigraphic Tracking of Allogeneic Mesenchymal Stem Cells in the Distal Limb After Intra-Arterial Injection in Standing Horses publication-title: Veter Surg. doi: 10.1111/vsu.12485 contributor: fullname: Espinosa – volume: 8 start-page: 5610 year: 2018 ident: ref_80 article-title: Longitudinal intravital imaging of transplanted mesenchymal stem cells elucidates their functional integration and therapeutic potency in an animal model of interstitial cystitis/bladder pain syndrome publication-title: Theranostics doi: 10.7150/thno.27559 contributor: fullname: Ryu – volume: 27 start-page: 291 year: 2016 ident: ref_79 article-title: Mesenchymal stem cell therapy in a rat model of birth-trauma injury: Functional improvements and biodistribution publication-title: Int. Urogynecol. J. doi: 10.1007/s00192-015-2831-5 contributor: fullname: Sadeghi – volume: 26 start-page: 986 year: 2017 ident: ref_102 article-title: Long-Term In Vivo Monitoring of Adult-Derived Human Liver Stem/Progenitor Cells by Bioluminescence Imaging, Positron Emission Tomography, and Contrast-Enhanced Computed Tomography publication-title: Stem Cells Dev. doi: 10.1089/scd.2016.0338 contributor: fullname: Hsu – volume: 11 start-page: 1 year: 2020 ident: ref_127 article-title: Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-020-01770-z contributor: fullname: Patrick – volume: 10 start-page: 1 year: 2020 ident: ref_60 article-title: In vivo stem cell tracking using scintigraphy in a canine model of DMD publication-title: Sci. Rep. contributor: fullname: Thibaud – volume: 6 start-page: 31 year: 2015 ident: ref_101 article-title: Therapeutic efficacy and biodistribution of allogeneic mesenchymal stem cells delivered by intrasplenic and intrapancreatic routes in streptozotocin-induced diabetic mice publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-015-0017-1 contributor: fullname: Yaochite – volume: 41 start-page: 2527 year: 2018 ident: ref_29 article-title: Tracking of transplanted human umbilical cord-derived mesenchymal stem cells labeled with fluorescent probe in a mouse model of acute lung injury publication-title: Int. J. Mol. Med. contributor: fullname: Liu – volume: 5 start-page: 54 year: 2009 ident: ref_25 article-title: Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.05.003 contributor: fullname: Lee – volume: 142 start-page: 1033 year: 2018 ident: ref_50 article-title: In vivo tracking of the tropism of mesenchymal stem cells to malignant gliomas using reporter gene-based MR imaging publication-title: Int. J. Cancer doi: 10.1002/ijc.31113 contributor: fullname: Cao – volume: 11 start-page: 34 year: 2015 ident: ref_134 article-title: Route of delivery influences biodistribution of human bone marrow-derived mesenchymal stromal cells following experimental bone marrow transplantation publication-title: J. Stem Cells Regen. Med. doi: 10.46582/jsrm.1102007 contributor: fullname: Wang – ident: ref_103 doi: 10.3389/fimmu.2017.00638 – volume: 91 start-page: 1003 year: 2012 ident: ref_123 article-title: Interplay between Mesenchymal Stem Cells and Lymphocytes: Implications for Immunotherapy and Tissue Regeneration publication-title: J. Dent. Res. doi: 10.1177/0022034512460404 contributor: fullname: Wang – volume: 11 start-page: 100 year: 2019 ident: ref_92 article-title: Triple-modal imaging of stem-cells labeled with multimodal nanoparticles, applied in a stroke model publication-title: World J. Stem Cells doi: 10.4252/wjsc.v11.i2.100 contributor: fullname: Mamani – volume: 8 start-page: 315 year: 2006 ident: ref_12 article-title: Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement publication-title: Cytotherapy doi: 10.1080/14653240600855905 contributor: fullname: Dominici – volume: 195 start-page: 492 year: 1991 ident: ref_7 article-title: In vitro differentiation of bone and hypertrophic cartilage from periosteal-derived cells publication-title: Exp. Cell Res. doi: 10.1016/0014-4827(91)90401-F contributor: fullname: Nakahara – volume: 98 start-page: 145 year: 2015 ident: ref_98 article-title: Intranasal delivery of stem cells as therapy for central nervous system disease publication-title: Exp. Mol. Pathol. doi: 10.1016/j.yexmp.2015.01.016 contributor: fullname: Li – volume: 5 start-page: 1 year: 2015 ident: ref_108 article-title: Novel 89Zr cell labeling approach for PET-based cell trafficking studies publication-title: EJNMMI Res. doi: 10.1186/s13550-015-0098-y contributor: fullname: Bansal – volume: 4 start-page: 1073 year: 2015 ident: ref_52 article-title: Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of Parkinson’s Disease, Focusing on Cell Distribution and Neuroprotective and Behavioral Effects publication-title: Stem Cells Transl. Med. doi: 10.5966/sctm.2015-0023 contributor: fullname: Cerri – volume: 25 start-page: 2739 year: 2007 ident: ref_11 article-title: Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing publication-title: Stem Cells doi: 10.1634/stemcells.2007-0197 contributor: fullname: Chamberlain – ident: ref_111 doi: 10.1136/bmjresp-2018-000308 – volume: 101 start-page: 2999 year: 2003 ident: ref_26 article-title: Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates publication-title: Blood doi: 10.1182/blood-2002-06-1830 contributor: fullname: Devine – volume: 9 start-page: 1 year: 2018 ident: ref_105 article-title: Porcine Wharton’s jelly cells distribute throughout the body after intraperitoneal injection publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-018-0775-7 contributor: fullname: Packthongsuk – volume: 77 start-page: 11 year: 2015 ident: ref_4 article-title: Bone marrow stromal cells as immunomodulators. A primer for dermatologists publication-title: J. Dermatol. Sci. doi: 10.1016/j.jdermsci.2014.10.004 contributor: fullname: Nemeth – volume: 20 start-page: 806 year: 2018 ident: ref_20 article-title: Intrathecal administration of autologous mesenchymal stromal cells for spinal cord injury: Safety and efficacy of the 100/3 guideline publication-title: Cytotherapy doi: 10.1016/j.jcyt.2018.03.032 contributor: fullname: Vaquero – volume: 19 start-page: 2108 year: 2015 ident: ref_82 article-title: Human umbilical cord mesenchymal stem cell transplantation restores damaged ovaries publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.12571 contributor: fullname: Zhu – volume: 22 start-page: 3552 year: 2016 ident: ref_87 article-title: Intracerebral and Intravenous Transplantation Represents a Favorable Approach for Application of Human Umbilical Cord Mesenchymal Stromal Cells in Intracerebral Hemorrhage Rats publication-title: Med. Sci. Monit. doi: 10.12659/MSM.900512 contributor: fullname: Xie – volume: 19 start-page: 31 year: 2016 ident: ref_100 article-title: In Vivo Bioluminescence Imaging of Transplanted Mesenchymal Stromal Cells and Their Rejection Mediated by Intrahepatic NK Cells publication-title: Mol. Imaging Biol. doi: 10.1007/s11307-016-0962-9 contributor: fullname: Liu – volume: 35 start-page: 399 year: 2015 ident: ref_56 article-title: Intra-arterial transplantation of low-dose stem cells provides functional recovery without adverse effects after stroke publication-title: Cell Mol. Neurobiol. doi: 10.1007/s10571-014-0135-9 contributor: fullname: Fukuda – volume: 16 start-page: 525 year: 2019 ident: ref_85 article-title: Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodeficiency Mice: Preclinical Study publication-title: Tissue Eng. Regen. Med. doi: 10.1007/s13770-019-00202-1 contributor: fullname: Quesada – volume: 52 start-page: 543 year: 2017 ident: ref_106 article-title: Local application of adipose-derived mesenchymal stem cells supports the healing of fistula: Prospective randomised study on rat model of fistulising Crohn’s disease publication-title: Scand. J. Gastroenterol. doi: 10.1080/00365521.2017.1281434 contributor: fullname: Ryska – volume: 31 start-page: 414 year: 2017 ident: ref_15 article-title: Mesenchymal stromal cells: Properties and role in management of cutaneous diseases publication-title: J. Eur. Acad. Dermatol. Venereol. doi: 10.1111/jdv.13934 contributor: fullname: Kim – volume: 19 start-page: 839 year: 2017 ident: ref_37 article-title: Intravenous infusion of adipose-derived stem/stromal cells improves functional recovery of rats with spinal cord injury publication-title: Cytotherapy doi: 10.1016/j.jcyt.2017.04.002 contributor: fullname: Ohta – volume: 11 start-page: 7771 year: 2019 ident: ref_121 article-title: Intracellular dynamics of superparamagnetic iron oxide nanoparticles for magnetic particle imaging publication-title: Nanoscale doi: 10.1039/C9NR01395D contributor: fullname: Teeman – volume: 46 start-page: 36 year: 2017 ident: ref_21 article-title: Intraarticular and intravenous administration of (99M)Tc-HMPAO-labeled human mesenchymal stem cells ((99M)TC-AH-MSC(S)): In vivo imaging and biodistribution publication-title: Nucl. Med. Biol. doi: 10.1016/j.nucmedbio.2016.12.003 contributor: fullname: Montellano – volume: 29 start-page: 1497 year: 2015 ident: ref_90 article-title: Effects of local administration of allogenic adipose tissue-derived mesenchymal stem cells on functional recovery in experimental traumatic brain injury publication-title: Brain Inj. doi: 10.3109/02699052.2015.1053525 contributor: fullname: Melen – volume: 112 start-page: 1451 year: 2005 ident: ref_24 article-title: Dynamic Imaging of Allogeneic Mesenchymal Stem Cells Trafficking to Myocardial Infarction publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.537480 contributor: fullname: Kraitchman – volume: 28 start-page: 1224 year: 2019 ident: ref_57 article-title: Mesenchymal Stromal Cells Are Retained in the Porcine Renal Cortex Independently of Their Metabolic State After Renal Intra-Arterial Infusion publication-title: Stem Cells Dev. doi: 10.1089/scd.2019.0105 contributor: fullname: Munk – ident: ref_68 doi: 10.3791/56273-v – volume: 36 start-page: 1151 year: 2016 ident: ref_129 article-title: Splenectomy enhances the therapeutic effect of adipose tissue-derived mesenchymal stem cell infusion on cirrhosis rats publication-title: Liver Int. doi: 10.1111/liv.12962 contributor: fullname: Tang – volume: 19 start-page: 61 year: 2017 ident: ref_28 article-title: Human mesenchymal stromal cells undergo apoptosis and fragmentation after intravenous application in immune-competent mice publication-title: Cytotherapy doi: 10.1016/j.jcyt.2016.09.010 contributor: fullname: Leibacher – volume: 9 start-page: 1 year: 2018 ident: ref_48 article-title: Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-018-1076-x contributor: fullname: Scarfe – volume: 9 start-page: 1 year: 2018 ident: ref_71 article-title: Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-018-0900-7 contributor: fullname: Khan – volume: 8 start-page: 1 year: 2018 ident: ref_16 article-title: Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking publication-title: Sci. Rep. doi: 10.1038/s41598-018-22750-7 contributor: fullname: Ezquer – volume: 106 start-page: 217 year: 2016 ident: ref_30 article-title: Targeted systemic mesenchymal stem cell delivery using hyaluronate—wheat germ agglutinin conjugate publication-title: Biomaterials doi: 10.1016/j.biomaterials.2016.08.027 contributor: fullname: Kim – volume: 5 start-page: 1668 year: 2016 ident: ref_43 article-title: Biodistribution and Clearance of Human Mesenchymal Stem Cells by Quantitative Three-Dimensional Cryo-Imaging After Intravenous Infusion in a Rat Lung Injury Model publication-title: Stem Cells Transl. Med. doi: 10.5966/sctm.2015-0379 contributor: fullname: Schmuck – volume: 9 start-page: 131 year: 2020 ident: ref_114 article-title: Fate of systemically and locally administered adipose-derived mesenchymal stromal cells and their effect on wound healing publication-title: STEM CELLS Transl. Med. doi: 10.1002/sctm.19-0091 contributor: fullname: Kallmeyer – ident: ref_120 doi: 10.3791/740 – volume: 33 start-page: 265 year: 2015 ident: ref_139 article-title: Intravital Imaging of Mesenchymal Stem Cell Trafficking and Association With Platelets and Neutrophils publication-title: Stem Cells doi: 10.1002/stem.1848 contributor: fullname: Teo – ident: ref_84 doi: 10.3390/ijms21041272 – volume: 98 start-page: 2396 year: 2001 ident: ref_1 article-title: Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow publication-title: Blood doi: 10.1182/blood.V98.8.2396 contributor: fullname: Campagnoli – volume: 295 start-page: F315 year: 2008 ident: ref_47 article-title: Bioluminescence imaging to monitor the in vivo distribution of administered mesenchymal stem cells in acute kidney injury publication-title: Am. J. Physiol. Physiol. doi: 10.1152/ajprenal.00098.2008 contributor: fullname: Yang – volume: 43 start-page: 410 year: 2016 ident: ref_119 article-title: Imaging and 1-day kinetics of intracoronary stem cell transplantation in patients with idiopathic dilated cardiomyopathy publication-title: Nucl. Med. Biol. doi: 10.1016/j.nucmedbio.2015.12.003 contributor: fullname: Lezaic – ident: ref_137 doi: 10.1038/srep42793 – volume: 18 start-page: 160 year: 2016 ident: ref_125 article-title: Mesenchymal stromal cells and immunomodulation: A gathering of regulatory immune cells publication-title: Cytotherapy doi: 10.1016/j.jcyt.2015.10.011 contributor: fullname: Najar – volume: 27 start-page: 415 year: 2018 ident: ref_63 article-title: Human Umbilical Cord Perivascular Cells and Human Bone Marrow Mesenchymal Stromal Cells Transplanted Intramuscularly Respond to a Distant Source of Inflammation publication-title: Stem Cells Dev. doi: 10.1089/scd.2017.0248 contributor: fullname: Estrada – volume: 8 start-page: 456 year: 2019 ident: ref_65 article-title: Concise Review: Skeletal Muscle as a Delivery Route for Mesenchymal Stromal Cells publication-title: Stem Cells Transl. Med. doi: 10.1002/sctm.18-0208 contributor: fullname: Davies – volume: 9 start-page: 1 year: 2019 ident: ref_75 article-title: Intra-articularly injected mesenchymal stem cells promote cartilage regeneration, but do not permanently engraft in distant organs publication-title: Sci. Rep. contributor: fullname: Ginner – volume: 22 start-page: 226 year: 2016 ident: ref_14 article-title: Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoblasts and Adipocytes and its Role in Treatment of Osteoporosis publication-title: Med. Sci. Monit. doi: 10.12659/MSM.897044 contributor: fullname: Wang – volume: 6 start-page: 28 year: 2019 ident: ref_6 article-title: Isolation of umbilical cord mesenchymal stem cells using human blood derivatives accompanied with explant method publication-title: Stem Cell Investig. doi: 10.21037/sci.2019.08.06 contributor: fullname: Hassan – volume: 8 start-page: 1 year: 2017 ident: ref_46 article-title: Distribution pattern following systemic mesenchymal stem cell injection depends on the age of the recipient and neuronal health publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-017-0533-2 contributor: fullname: Fabian – volume: 37 start-page: 1363 year: 2015 ident: ref_33 article-title: In vivo magnetic resonance imaging of iron oxide-labeled, intravenous-injected mesenchymal stem cells in kidneys of rabbits with acute ischemic kidney injury: Detection and monitoring at 1.5 T publication-title: Ren. Fail. doi: 10.3109/0886022X.2015.1073542 contributor: fullname: Zhang – volume: 13 start-page: 127 year: 2017 ident: ref_89 article-title: Magnetic Resonance Imaging of Ferumoxytol-Labeled Human Mesenchymal Stem Cells in the Mouse Brain publication-title: Stem Cell Rev. Rep. doi: 10.1007/s12015-016-9694-0 contributor: fullname: Lee – volume: 81 start-page: 437 year: 2016 ident: ref_31 article-title: Human umbilical cord-derived mesenchymal stem cells in acute liver injury: Hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution publication-title: Regul. Toxicol. Pharmacol. doi: 10.1016/j.yrtph.2016.09.029 contributor: fullname: Yun – volume: 25 start-page: 2199 year: 2016 ident: ref_72 article-title: Long-Term Cell Tracking following Local Injection of Mesenchymal Stromal Cells in the Equine Model of Induced Tendon Disease publication-title: Cell Transplant. doi: 10.3727/096368916X692104 contributor: fullname: Burk – volume: 17 start-page: 185 year: 2014 ident: ref_45 article-title: Optimization of Mesenchymal Stem Cells (MSCs) Delivery Dose and Route in Mice with Acute Liver Injury by Bioluminescence Imaging publication-title: Mol. Imaging Biol. doi: 10.1007/s11307-014-0792-6 contributor: fullname: Li – volume: 25 start-page: 401 year: 2016 ident: ref_58 article-title: Intra-arterial Administration of Placenta-Derived Decidual Stromal Cells to the Superior Mesenteric Artery in the Rabbit: Distribution of Cells, Feasibility, and Safety publication-title: Cell Transplant. doi: 10.3727/096368915X688191 contributor: fullname: Arnberg – volume: 17 start-page: 452 year: 2017 ident: ref_41 article-title: In vivo monitoring of magnetically labeled mesenchymal stem cells homing to rabbit hepatic VX2 tumors using magnetic resonance imaging publication-title: Mol. Med. Rep. contributor: fullname: Qin – volume: 15 start-page: 243 year: 2015 ident: ref_97 article-title: Longitudinal tracking of triple labeled umbilical cord derived mesenchymal stromal cells in a mouse model of Amyotrophic Lateral Sclerosis publication-title: Stem Cell Res. doi: 10.1016/j.scr.2015.06.010 contributor: fullname: Violatto – volume: 25 start-page: 1134 year: 2016 ident: ref_42 article-title: Mesenchymal Stromal/Stem Cells Do Not Ameliorate Experimental Autoimmune Encephalomyelitis and Are Not Detectable in the Central Nervous System of Transplanted Mice publication-title: Stem Cells Dev. doi: 10.1089/scd.2016.0020 contributor: fullname: Abramowski – volume: 2016 start-page: 1 year: 2016 ident: ref_135 article-title: The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs publication-title: Stem Cells Int. doi: 10.1155/2016/8616143 contributor: fullname: Jin – volume: 7 start-page: 75 year: 2012 ident: ref_2 article-title: Mesenchymal stem cells, sources of cells and differentiation potential publication-title: J. Stem Cells contributor: fullname: Khan – ident: ref_66 doi: 10.1371/journal.pone.0114962 – volume: 21 start-page: 546 year: 2019 ident: ref_112 article-title: In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials publication-title: Cytotherapy doi: 10.1016/j.jcyt.2018.12.005 contributor: fullname: Tappenbeck – volume: 17 start-page: 832 year: 2015 ident: ref_13 article-title: Mesenchymal stromal cells and rheumatic diseases: New tools from pathogenesis to regenerative therapies publication-title: Cytotherapy doi: 10.1016/j.jcyt.2014.12.006 contributor: fullname: Cipriani – volume: 25 start-page: 195 year: 2016 ident: ref_35 article-title: Biodistribution of Infused Human Umbilical Cord Blood Cells in Alzheimer’s Disease-Like Murine Model publication-title: Cell Transplant. doi: 10.3727/096368915X689604 contributor: fullname: Ehrhart – volume: 25 start-page: 1635 year: 2016 ident: ref_40 article-title: Pulmonary Retention of Adipose Stromal Cells following Intravenous Delivery is Markedly Altered in the Presence of ARDS publication-title: Cell Transplant. doi: 10.3727/096368915X690189 contributor: fullname: Lu – volume: 19 start-page: 384 year: 2017 ident: ref_61 article-title: Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction–based detection of human DNA in murine organs publication-title: Cytotherapy doi: 10.1016/j.jcyt.2016.12.003 contributor: fullname: Creane – volume: 24 start-page: 2379 year: 2015 ident: ref_69 article-title: In Vivo Tracking and Fate of Intra-Articularly Injected Superparamagnetic Iron Oxide Particle-Labeled Multipotent Stromal Cells in an Ovine Model of Osteoarthritis publication-title: Cell Transplant. doi: 10.3727/096368914X685654 contributor: fullname: Delling – volume: 201 start-page: 239 year: 2016 ident: ref_10 article-title: The Placenta as an Organ and a Source of Stem Cells and Extracellular Matrix: A Review publication-title: Cells Tissues Organs doi: 10.1159/000443636 contributor: fullname: Lobo – volume: 33 start-page: 1565 year: 2019 ident: ref_62 article-title: Cell tracking of chromium-labeled mesenchymal stem cells using laser ablation inductively coupled plasma imaging mass spectrometry publication-title: Rapid Commun. Mass Spectrom. doi: 10.1002/rcm.8505 contributor: fullname: Nakada – volume: 74 start-page: 2345 year: 2017 ident: ref_124 article-title: Interactions between mesenchymal stem cells and the immune system publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-017-2473-5 contributor: fullname: Li – volume: 162 start-page: 153 year: 2016 ident: ref_49 article-title: The Use of Technetium-99m for Intravital Tracing of Transplanted Multipotent Stromal Cells publication-title: Bull. Exp. Biol. Med. doi: 10.1007/s10517-016-3565-1 contributor: fullname: Silachev – volume: 97 start-page: 38 year: 2018 ident: ref_18 article-title: Cytotherapy using stromal cells: Current and advance multi-treatment approaches publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2017.10.127 contributor: fullname: Shende – volume: 39 start-page: 1569 year: 2008 ident: ref_133 article-title: Dual-Modality Monitoring of Targeted Intraarterial Delivery of Mesenchymal Stem Cells After Transient Ischemia publication-title: Stroke doi: 10.1161/STROKEAHA.107.502047 contributor: fullname: Walczak – volume: 9 start-page: 96 year: 2018 ident: ref_83 article-title: Safety and tracking of intrathecal allogeneic mesenchymal stem cell transplantation in healthy and diseased horses publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-018-0849-6 contributor: fullname: Barberini – volume: 32 start-page: 50 year: 2014 ident: ref_23 article-title: Mesenchymal Stromal Cell Therapy for Crohn’s Disease publication-title: Dig. Dis. doi: 10.1159/000367826 contributor: fullname: Liew – volume: 28 start-page: 1615 year: 2017 ident: ref_95 article-title: The Distribution of Transplanted Umbilical Cord Mesenchymal Stem Cells in Large Blood Vessel of Experimental Design With Traumatic Brain Injury publication-title: J. Craniofacial Surg. doi: 10.1097/SCS.0000000000003563 contributor: fullname: Dong – volume: 10 start-page: 473 year: 2015 ident: ref_131 article-title: MR tracking of SPIO-labeled mesenchymal stem cells in rats with liver fibrosis could not monitor the cells accurately publication-title: Contrast Media Mol. Imaging doi: 10.1002/cmmi.1650 contributor: fullname: Zhou – volume: 13 start-page: 4279 year: 2002 ident: ref_3 article-title: Human Adipose Tissue Is a Source of Multipotent Stem Cells publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e02-02-0105 contributor: fullname: Zuk – volume: 7 start-page: 1 year: 2016 ident: ref_67 article-title: In vivo human adipose-derived mesenchymal stem cell tracking after intra-articular delivery in a rat osteoarthritis model publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-016-0420-2 contributor: fullname: Li – volume: 23 start-page: 1 year: 2016 ident: ref_17 article-title: Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: Review of current clinical trials publication-title: J. Biomed. Sci. doi: 10.1186/s12929-016-0289-5 contributor: fullname: Wang – volume: 22 start-page: 904 year: 2020 ident: ref_55 article-title: Multimodal Imaging Techniques Show Differences in Homing Capacity between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models publication-title: Mol. Imaging Biol. doi: 10.1007/s11307-019-01458-8 contributor: fullname: Taylor – volume: 8 start-page: 467 year: 2015 ident: ref_76 article-title: In VivoKinetics of Mesenchymal Stem Cells Transplanted into the Knee Joint in a Rat Model Using a Novel Magnetic Method of Localization publication-title: Clin. Transl. Sci. doi: 10.1111/cts.12284 contributor: fullname: Ikuta – volume: 11 start-page: 954 year: 2014 ident: ref_91 article-title: Tracking of mesenchymal stem cells labeled with gadolinium diethylenetriamine pentaacetic acid by 7T magnetic resonance imaging in a model of cerebral ischemia publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2014.2805 contributor: fullname: Geng – volume: 47 start-page: 192 year: 2016 ident: ref_96 article-title: Distribution of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in canines after intracerebroventricular injection publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2016.08.002 contributor: fullname: Park – ident: ref_107 doi: 10.1371/journal.pone.0122377 – volume: 48 start-page: 1702 year: 2020 ident: ref_128 article-title: Cryo-imaging of Stem Cell Biodistribution in Mouse Model of Graft-Versus-Host-Disease publication-title: Ann. Biomed. Eng. doi: 10.1007/s10439-020-02487-z contributor: fullname: Wuttisarnwattana – volume: 63 start-page: 859 year: 2010 ident: ref_8 article-title: Skin mesenchymal stem cells: Prospects for clinical dermatology publication-title: J. Am. Acad. Dermatol. doi: 10.1016/j.jaad.2009.09.022 contributor: fullname: Sellheyer – volume: 24 start-page: 1124 year: 2015 ident: ref_73 article-title: Pharmacokinetics and In Vivo Fate of Intra-Articularly Transplanted Human Bone Marrow-Derived Clonal Mesenchymal Stem Cells publication-title: Stem Cells Dev. doi: 10.1089/scd.2014.0240 contributor: fullname: Shim – ident: ref_44 doi: 10.3390/ijms19092564 – volume: 22 start-page: 417 year: 2018 ident: ref_109 article-title: Systemic redistribution of the intramyocardially injected mesenchymal stem cells by repeated remote ischaemic post-conditioning publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.13331 contributor: fullname: Jiang – volume: 2016 start-page: 1 year: 2016 ident: ref_130 article-title: In VivoTracking of Systemically Administered Allogeneic Bone Marrow Mesenchymal Stem Cells in Normal Rats through Bioluminescence Imaging publication-title: Stem Cells Int. doi: 10.1155/2016/3970942 contributor: fullname: Cao – volume: 8 start-page: 272 year: 2017 ident: ref_136 article-title: Tracing GFP-labeled WJMSCs in vivo using a chronic salpingitis model: An animal experiment publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-017-0714-z contributor: fullname: Li – volume: 10 start-page: 1 year: 2020 ident: ref_93 article-title: Magnetic resonance imaging of umbilical cord stem cells labeled with superparamagnetic iron oxide nanoparticles: Effects of labelling and transplantation parameters publication-title: Sci. Rep. doi: 10.1038/s41598-020-70291-9 contributor: fullname: Ohki – volume: 105 start-page: 131 year: 2017 ident: ref_64 article-title: Effective tracking of bone mesenchymal stem cells in vivo by magnetic resonance imaging using melanin-based gadolinium(3+) nanoparticles publication-title: J. Biomed. Mater. Res. A doi: 10.1002/jbm.a.35891 contributor: fullname: Cai |
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| SubjectTerms | Adipocytes Alzheimer's disease Biodistribution Clinical medicine Heart attacks Kidneys Liver Lungs Review Spinal cord Stem cells Systematic review |
| Title | Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review |
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