Pulsating fluid flow affects pre‐osteoblast behavior and osteogenic differentiation through production of soluble factors

Bone mass increases after error‐loading, even in the absence of osteocytes. Loaded osteoblasts may produce a combination of growth factors affecting adjacent osteoblast differentiation. We hypothesized that osteoblasts respond to a single load in the short‐term (minutes) by changing F‐actin stress f...

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Bibliographic Details
Published in:	Physiological reports Vol. 9; no. 12; pp. e14917 - n/a
Main Authors:	Jin, Jianfeng, Seddiqi, Hadi, Bakker, Astrid D., Wu, Gang, Verstappen, Johanna F. M., Haroon, Mohammad, Korfage, Joannes A. M., Zandieh‐Doulabi, Behrouz, Werner, Arie, Klein‐Nulend, Jenneke, Jaspers, Richard T.
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-06-2021 John Wiley and Sons Inc
Subjects:	Actin Actins - metabolism Actins - physiology Alkaline phosphatase Alkaline Phosphatase - metabolism Animals Bone growth Bone mass Boundary conditions Cbfa-1 protein Cell Differentiation - physiology Cell Line Collagen Collagen - metabolism Computer applications Cytoskeleton Fibroblast growth factor 2 Fibroblasts Finite Element Analysis finite element modeling Fluid dynamics Fluid flow F‐actin stress fiber Gene Expression Growth factors Mechanical loading Mechanical stimuli Metabolism Mice Mineralization Morphology Nitric oxide Nitric Oxide - metabolism Original Osteoblastogenesis Osteoblasts Osteoblasts - metabolism Osteoblasts - physiology Osteocytes Osteogenesis Osteogenesis - physiology osteogenic differentiation Physiology pre‐osteoblast Pseudopodia Pulsatile Flow - physiology Shear stress finite element modeling fluid dynamics osteogenic differentiation pre-osteoblast F-actin stress fiber
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