Reversible Splenial Lesion Syndrome (RESLES) Following Glufosinate Ammonium Poisoning

• Published in: Journal of neuroimaging Vol. 25; no. 6; pp. 1050 - 1052
• Main Authors: Jeong, Tae Oh, Yoon, Jae Chol, Lee, Jae Baek, Jin, Young Ho, Hwang, Seung Bae
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-11-2015
• Subjects: Adult; Aminobutyrates - poisoning; Brain Edema - chemically induced; Brain Edema - diagnostic imaging; Corpus callosum; Corpus Callosum - diagnostic imaging; Corpus Callosum - drug effects; cytotoxic edema; Diffusion Magnetic Resonance Imaging; Edema; Female; glufosinate ammonium; Humans; Neuroimaging; Poisoning; Remission, Spontaneous; Seizures - chemically induced; Seizures - diagnostic imaging; glufosinate ammonium; Corpus callosum; cytotoxic edema
• ISSN: 1051-2284; 1552-6569
• DOI: 10.1111/jon.12216

ABSTRACT
Isolated and reversible lesion restricted to the splenium of the corpus callosum, known as reversible splenial lesion syndrome, have been reported in patients with infection, high‐altitude cerebral edema, seizures, antiepileptic drug withdrawal, or metabolic disturbances. Here, we report a 39‐year‐old female patient with glufosinate ammonium (GLA) poisoning who presented with confusion and amnesia. Diffusion‐weighted magnetic resonance imaging of the brain revealed cytotoxic edema of the splenium of the corpus callosum. The lesion was not present on follow‐up MR imaging performed 9 months later. We postulate that a GLA‐induced excitotoxic mechanism was the cause of this reversible splenial lesion.