Costimulation Blockade—A Double‐Edged Sword?

The author describes the findings of Riella et al (see April issue) and Charbonnier et al (see page 2313) that CTLA4Ig worsens outcomes in regulatory T cell–dependent models of transplantation and discusses how these findings may impact future research and clinical use of related drugs.

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Bibliographic Details
Published in:	American journal of transplantation Vol. 12; no. 9; pp. 2269 - 2270
Main Author:	Maltzman, J. S.
Format:	Journal Article
Language:	English
Published:	Malden, USA Blackwell Publishing Inc 01-09-2012
Subjects:	Abatacept Animals Graft Rejection - immunology Graft Survival - immunology Heart Transplantation - immunology Histocompatibility Antigens Class II - immunology Immunoconjugates - administration & dosage Immunoconjugates - therapeutic use Immunosuppressive Agents - therapeutic use Interleukin-2 - administration & dosage Riella T-Lymphocytes, Regulatory - immunology Thymus Gland - immunology
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Description
Summary:	The author describes the findings of Riella et al (see April issue) and Charbonnier et al (see page 2313) that CTLA4Ig worsens outcomes in regulatory T cell–dependent models of transplantation and discusses how these findings may impact future research and clinical use of related drugs.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1600-6135 1600-6143
DOI:	10.1111/j.1600-6143.2012.04185.x