Potent CaV3.2 channel inhibitors exert analgesic effects in acute and chronic pain models

Pain is the most common presenting physical symptom and a primary reason for seeking medical care, which chronically affects people's mental health and social life. CaV3.2 channel plays an essential role in the peripheral processing maintenance of pain states. This study was designed to identif...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 153; p. 113310
Main Authors:	Kamau, Peter Muiruri, Li, Hao, Yao, Zhihao, Han, Yalan, Luo, Anna, Zhang, Hao, Boonyarat, Chantana, Yenjai, Chavi, Mwangi, James, Zeng, Lin, Yang, Shilong, Lai, Ren, Luo, Lei
Format:	Journal Article
Language:	English
Published:	Elsevier Masson SAS 01-09-2022 Elsevier
Subjects:	Analgesic activity CaV3.2 Drug design Pain Toddaculin Toddaculin HEK293T CaVs i.col VSD i.p siRNA CaV3.2 PDB AP Pain NaVs RMP ANOVA SI RT-PCR IC50 DRG Drug design cryo-EM ODNs US Analgesic activity
Online Access:	Get full text
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