The association between de novo inflammatory bowel disease and celiac disease

• Published in: Revista española de enfermedades digestivas Vol. 112; no. 1; pp. 7 - 11
• Main Authors: Manceñido Marcos, Noemí, Pajares Villarroya, Ramón, Salinas Moreno, Silvia, Arribas López, M Rosario, Comas Redondo, Carmen
• Format: Journal Article
• Language: English
• Published: Spain Sociedad Espanola de Patologia Digestivas 01-01-2020
• Subjects: Adolescent; Adult; Aged; Celiac Disease - diagnosis; Celiac Disease - epidemiology; Celiac Disease - immunology; Colitis, Ulcerative - complications; Crohn Disease - complications; Female; GTP-Binding Proteins - immunology; Humans; Immunoglobulin A - blood; Immunoglobulin G - blood; Male; Middle Aged; Prevalence; Retrospective Studies; Spain; Transglutaminases - immunology; Young Adult; Spain; España
• ISSN: 1130-0108
• DOI: 10.17235/reed.2019.5535/2018

controversial data have been reported on the potential association between celiac disease (CeD) and inflammatory bowel disease (IBD).
to study the prevalence of CeD in patients newly diagnosed cases with IBD.
an observational, retrospective study was performed in patients with newly diagnosed IBD who were screened for CeD by anti-tissue transglutaminase antibodies (anti-tTG) measurements and an endoscopic duodenal biopsy. No patients had received corticosteroids, immunosuppressants or biologic drugs within the three months prior to gastroscopy. In the presence of Marsh 1, other causes were ruled out. CeD was diagnosed in patients positive for anti-tTG, compatible duodenal biopsy findings and a good response to a gluten-free diet.
a total of 163 patients were screened for CeD. Of these, six (3.7%) were positive for anti-tTG and four were diagnosed with CeD (three had ulcerative colitis, one had Crohn's disease). All patients with both CeD and IBD had normal IgA levels, positive anti-tTG and CeD genetic markers.
the prevalence of CeD in our patients with IBD was higher than that reported in the literature for other series of patients with IBD. A combination of anti-tTG testing and CeD genetics may screen patients for CeD in this population of patients with IBD.