The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth

• Published in: Microbiome Vol. 12; no. 1; pp. 99 - 10
• Main Authors: Schuster, H J, Breedveld, A C, Matamoros, S P F, van Eekelen, R, Painter, R C, Kok, M, Hajenius, P J, Savelkoul, P H M, van Egmond, M, van Houdt, R
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28-05-2024; BioMed Central; BMC
• Subjects: Adult; Case-Control Studies; Coatings; Ethnicity; Female; Host Microbial Interactions; Host-microbiota interaction; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulins; Infants (Premature); Inflammation; Lactobacillus - isolation & purification; Microbiota; Microbiota (Symbiotic organisms); Nulliparous women; Pregnancy; Pregnant women; Premature Birth - ethnology; Premature Birth - microbiology; Prospective Studies; Spontaneous preterm birth; Vagina - microbiology; Vaginal microbiota; Young Adult; Ethnicity; Immunoglobulins; Nulliparous women; Spontaneous preterm birth; Vaginal microbiota; Host-microbiota interaction
• ISSN: 2049-2618; 2049-2618
• DOI: 10.1186/s40168-024-01787-z

Vaginal microbiota composition is associated with spontaneous preterm birth (sPTB), depending on ethnicity. Host-microbiota interactions are thought to play an important underlying role in this association between ethnicity, vaginal microbiota and sPTB.
In a prospective cohort of nulliparous pregnant women, we assessed vaginal microbiota composition, vaginal immunoglobulins (Igs), and local inflammatory markers. We performed a nested case-control study with 19 sPTB cases, matched based on ethnicity and midwifery practice to 19 term controls.
Of the 294 included participants, 23 pregnancies ended in sPTB. We demonstrated that Lactobacillus iners-dominated microbiota, diverse microbiota, and ethnicity were all independently associated with sPTB. Microbial Ig coating was associated with both microbiota composition and ethnicity, but a direct association with sPTB was lacking. Microbial IgA and IgG coating were lowest in diverse microbiota, especially in women of any ethnic minority. When correcting for microbiota composition, increased microbial Ig coating correlated with increased inflammation.
In these nulliparous pregnant women, vaginal microbiota composition is strongly associated with sPTB. Our results support that vaginal mucosal Igs might play a pivotal role in microbiota composition, microbiota-related inflammation, and vaginal community disparity within and between ethnicities. This study provides insight in host-microbe interaction, suggesting that vaginal mucosal Igs play an immunomodulatory role similar to that in the intestinal tract. Video Abstract.