Dendritic cell cross talk with innate and innate-like effector cells in antitumor immunity: implications for DC vaccination

• Published in: Critical reviews in immunology Vol. 34; no. 6; pp. 517 - 536
• Main Authors: van Beek, Jasper J P, Wimmers, Florian, Hato, Stanleyson V, de Vries, I Jolanda M, Sköld, Annette E
• Format: Journal Article
• Language: English
• Published: United States 2014
• Subjects: Adoptive Transfer; Animals; Antigens, Neoplasm - genetics; Antigens, Neoplasm - immunology; Cancer Vaccines - administration & dosage; Cancer Vaccines - genetics; Cancer Vaccines - immunology; CD4-Positive T-Lymphocytes - cytology; CD4-Positive T-Lymphocytes - immunology; Cell Communication - immunology; Dendritic Cells - cytology; Dendritic Cells - immunology; Dendritic Cells - transplantation; Gene Expression Regulation, Neoplastic; Humans; Immunity, Innate; Killer Cells, Natural - cytology; Killer Cells, Natural - immunology; Medicin och hälsovetenskap; Mice; Neoplasms - immunology; Neoplasms - pathology; Neoplasms - prevention & control; Receptors, Antigen, T-Cell, gamma-delta - genetics; Receptors, Antigen, T-Cell, gamma-delta - immunology; Signal Transduction; T-Lymphocytes, Cytotoxic - cytology; T-Lymphocytes, Cytotoxic - immunology; Vaccination
• ISSN: 1040-8401; 2162-6472
• DOI: 10.1615/CritRevImmunol.2014012204

Dendritic cells (DCs) are key players in the induction of immune responses. Adoptive transfer of autologous mature DCs loaded with tumor-associated antigens is a promising therapy for the treatment of immunogenic tumors. For a long time, its therapeutic activity was thought to depend solely on the induction of tumor-specific CD8+ and CD4+ T cell responses. More recently, DCs were shown to bidirectionally interact with innate and innate-like immune cells, including natural killer (NK), invariant natural killer T (iNKT), and γδ T cells. These effector cells can amplify responses induced by DCs via several mechanisms, including induction of DC maturation and conventional T cell priming. In addition, NK, iNKT, and γδ T cells possess cytolytic activity and can act directly on tumor cells. Therapeutic strategies targeting these innate and innate-like immune cells hence hold potential to improve current DC vaccination protocols.