Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms

• Published in: Journal of the neurological sciences Vol. 418; p. 117090
• Main Authors: Neumann, Bernhard, Schmidbauer, Moritz L., Dimitriadis, Konstatinos, Otto, Sören, Knier, Benjamin, Niesen, Wolf-Dirk, Hosp, Jonas A., Günther, Albrecht, Lindemann, Sarah, Nagy, Gabor, Steinberg, Tim, Linker, Ralf A., Hemmer, Bernhard, Bösel, Julian
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15-11-2020
• Subjects: Adult; Aged; Aged, 80 and over; Cerebrospinal fluid; COVID-19; COVID-19 - cerebrospinal fluid; COVID-19 - complications; COVID-19 - virology; Female; Humans; Letter to the Editor; Male; Middle Aged; Nervous System Diseases - cerebrospinal fluid; Nervous System Diseases - complications; Nervous System Diseases - diagnosis; Nervous System Diseases - virology; Neurological symptoms; Pandemics; Polymerase Chain Reaction; RNA, Viral - cerebrospinal fluid; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - isolation & purification; COVID-19; SARS-CoV-2; PANDEMIC; IGNITE; LP; RT-PCR; CSF; Neurological symptoms; WBC; Cerebrospinal fluid
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2020.117090

•Largest cohort of patients with COVID-19 and neurological symptoms who underwent LP.•In all 30 cases, RT-PCR for SARS-CoV-2 from CSF was negative.•CSF analysis findings, including WBC, were normal in most patients with COVID-19.•Neurological symptoms in COVID-19 seem to be caused mainly by indirect mechanism.