Integrated BioNMR – “getting by with a little help from my friends”

[Display omitted] •The multidisciplinary nature of biological NMR spectroscopy is discussed.•Integration of solution and MAS NMR spectroscopy is described for the HIV-1 capsid.•Advantages of fluorine NMR and current efforts to develop this tool are outlined. Single types of methodologies are insuffi...

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Bibliographic Details
Published in:	Journal of magnetic resonance (1997) Vol. 306; pp. 192 - 194
Main Author:	Gronenborn, A.M.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-09-2019
Subjects:	BioNMR F-NMR Integrative structural biology MAS NMR Solution NMR BioNMR F-NMR Integrative structural biology Solution NMR MAS NMR
Online Access:	Get full text
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Summary:	[Display omitted] •The multidisciplinary nature of biological NMR spectroscopy is discussed.•Integration of solution and MAS NMR spectroscopy is described for the HIV-1 capsid.•Advantages of fluorine NMR and current efforts to develop this tool are outlined. Single types of methodologies are insufficient to adequately describe complex biological structures. As a result, integrated approaches that combine complementary data are being developed. Here, I describe the benefits of integrating solution and magic angle spinning BioNMR approaches to characterize structure and dynamics of protein assemblies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2
ISSN:	1090-7807 1096-0856
DOI:	10.1016/j.jmr.2019.07.040