Synthesis, characterization and antimicrobial screening of substituted quiazolinones derivatives

Synthesis, characterization and antimicrobial screening of substituted quiazolinones derivatives

A series of new quinazolinone derivatives have been synthesized. Elemental analysis, IR, 1H NMR and mass spectral data elucidated the structures of all newly synthesized compounds. In vitro antimicrobial activities of the synthesized compounds were investigated against Gram-positive Bacillus subtili...

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Bibliographic Details
Published in:Arabian journal of chemistry Vol. 8; no. 4; pp. 474 - 479
Main Authors: Mandhane, Priyanka G., Joshi, Ratnadeep S., Mahajan, Pravin S., Nikam, Mukesh D., Nagargoje, Deepak R., Gill, Charansingh H.
Format: Journal Article
Language:English
Published: Elsevier B.V 01-07-2015
Elsevier
Subjects:
Antimicrobial activity
Quinazolinone
Quinoline
Quinoline
Antimicrobial activity
Quinazolinone
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Summary:A series of new quinazolinone derivatives have been synthesized. Elemental analysis, IR, 1H NMR and mass spectral data elucidated the structures of all newly synthesized compounds. In vitro antimicrobial activities of the synthesized compounds were investigated against Gram-positive Bacillus subtilis (ATCC No. 6633), Staphylococcus aureus (ATCC No. 25923), Gram-negative Salmonella typhimurium (ATCC No. 23564), Pseudomonas aeruginosa (ATCC No. 27853) and fungi Candida albicans and Aspergillus niger. Among all the tested compounds, some of the tested compounds showed equipotent activity with standard.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2011.01.025