Antihypertriglyceridemia activities of naturally fermented green tea, Heukcha, extract through modulation of lipid metabolism in rats fed a high-fructose diet

• Published in: Food science and biotechnology Vol. 30; no. 12; pp. 1581 - 1591
• Main Authors: Jeong, Hyun Woo, Lee, Ji-Hae, Choi, Jin Kyu, Rha, Chan-Su, Lee, Jung Dae, Park, Jaehong, Park, Miyoung
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01-11-2021; Springer Nature B.V
• Subjects: Blood; Calculi; Cardiovascular diseases; Chemistry; Chemistry and Materials Science; Fatty acids; Fish oils; Food Science; Fructose; Gene expression; Genes; Green tea; Health risks; Hepatotoxicity; Hypertriglyceridemia; Lipid metabolism; Lipids; Metabolic disorders; Nutrition; Oxidation; Research Article; Risk analysis; Risk factors; Side effects; Tea; Triglycerides; Pancreatic lipase; Lipid metabolism; Naturally fermented green tea; Hypertriglyceridemia
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-021-00992-y

Hypertriglyceridemia, a symptom of elevated triglyceride level in the blood, is a potent risk factor for cardiovascular and metabolic disorders. Among the numerous treatments to regulate circulating triglyceride levels, fibrates are widely used to treat hypertriglyceridemia, although they also have side effects such as hepatotoxicity and gallstone formation. In the present study, we aimed to investigate the blood triglyceride-lowering effects of a naturally fermented green tea extract (NFGT) and the underlying mechanisms on hypertriglyceridemia in vitro and in vivo models. NFGT suppressed the expression of lipogenic genes, while augmented expression of fatty acid oxidation-related genes in cultured cells, leading to the significant decrease of intracellular triglyceride content. NFGT treated group in fructose-induced hypertriglyceridemic rat model significantly decreased plasma and hepatic triglyceride, which was accompanied by an increase in excretion of fecal fat. Taken together, we propose that NFGT could be potentially a novel functional ingredient to prevent or treat hypertriglyceridemia.